The role of tumor necrosis factor-α receptors in atherosclerosis
The role of tumor necrosis factor-α receptors in atherosclerosis
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DOI：
10.1016/s1050-1738(97)00142-4
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发表时间：
1998-04-01
影响因子：
9.3
通讯作者：
Schreyer, SA
中科院分区：
文献类型：
--
作者：
LeBoeuf, RC;Schreyer, SA
肿瘤坏死因子-（TNF-α）-α是一种细胞因子，其表现出参与炎症、免疫调节和能量代谢的过多活性。TNF由许多细胞类型产生，包括动脉粥样硬化病变中发现的细胞，如活化的单核细胞或巨噬细胞、T和B淋巴细胞、肥大细胞和平滑肌细胞。两种受体介导TNF的功能，两种受体也存在于动脉壁细胞和参与病变发展的细胞上。小鼠基因工程缺乏表达的TNF和它的每一个受体现在是可用的，并被用来剖析这些分子的作用，在保护或发展动脉粥样硬化。肿瘤坏死因子受体在动脉粥样硬化中的作用是这篇综述的主要焦点。(C)1998年，Elsevier Science Inc.
Tumor necrosis factor-(TNF-alpha)-alpha is a cytokine exhibiting a plethora of activities involved in inflammation, immune regulation, and energy metabolism. TNF is produced by many cell types, including cells found in atherosclerotic lesions, such as activated monocytes or macrophages, T and B lymphocytes, mast cells, and smooth muscle cells. Two receptors mediate the functions of TNF, and both receptors are also present on cells of the artery wall and on cells involved in lesion development. Mice genetically engineer to lack expression of TNF and each of its receptors are now available and are being used to dissect the role of these molecules in protection from or development of atherosclerosis. The role of TNF receptors in atherosclerosis is the primary focus of this review. (C) 1998, Elsevier Science Inc.