Angiogenin gene-race interaction for resting and exercise BP phenotypes: the HERITAGE Family Study.
Angiogenin gene-race interaction for resting and exercise BP phenotypes: the HERITAGE Family Study.
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静息和运动血压表型的血管生成素基因-种族相互作用：HERITAGE 家族研究。
DOI：
10.1152/jappl.2001.90.4.1232
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发表时间：
2001
期刊：
影响因子：
--
通讯作者：
Bouchard,C
中科院分区：
文献类型：
--
作者：
Rivera,MA;Echegaray,M;Rankinen,T;Perusse,L;Rice,T;Gagnon,J;Leon,AS;Skinner,JS;Wilmore,JH;Rao,DC;Bouchard,C
我们研究了血管生成素基因多态性与20周耐力训练计划前后静息时和急性运动时血压（BP）之间的关系。受试者为737名血压正常和临界高血压受试者（257名黑人和480名白色人）。用PCR和Ava Ⅱ酶切检测该基因的多态性，得到一个253 bp的等位基因或一个194 + 59 bp的罕见等位基因。在训练前后分别测定静息和运动时[50 W;最大耗氧量的60%、80%和100%（V steco 2 max）]的收缩压（SBP）和舒张压。在黑人中，在静息状态和运动强度为60%、80%和100%的Vsteco 2 max时，罕见等位基因携带者在久坐状态下的校正SBP显著较低。在训练状态下，携带稀有等位基因者在静息状态和80%和100% Vsteco 2 max时的SBP显著低于非携带者（P< 0.05）。在黑人中观察到的基因型效应在白人中并不明显。此外，BP的变化（前后）与基因型无显著相关。总之，血管生成素基因AvaII多态性与黑人静息时和急性高强度运动后较低的SBP相关，但与白人无关。
We examined the association between an angiogenin gene polymorphism and blood pressure (BP) at rest and in response to acute exercise before and after a 20-wk endurance-training program. Subjects were 737 normotensive and borderline hypertensive subjects (257 black and 480 white). The polymorphism was detected by PCR and digestion withAvaII, yielding an allele of 253 bp or a rare allele of 194 + 59 bp. Resting and exercise [50 W; 60, 80, and 100% of maximal O2consumption (V˙o2 max)] systolic (SBP) and diastolic BP were determined before and after training. Among blacks, adjusted SBP in the sedentary state was significantly lower in carriers of the rare allele at rest and exercise intensities of 60, 80, and 100% ofV˙o2 max. In the trained state, carriers of the rare allele had a significantly (P< 0.05) lower SBP than did noncarriers at rest and at 80 and 100% ofV˙o2 max. The genotypic effect observed among blacks was not evident among whites. Furthermore, change in BP (after − before) was not significantly associated with the genotype. In conclusion, the angiogenin geneAvaII polymorphism is associated with a lower SBP at rest and in response to acute high-intensity exercise in blacks but not in whites.
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人类血管生成素基因定位于染色体带 14q11，靠近 T 细胞受体 α/δ 基因座。
影响因子：
9.8
作者：
S. Weremowicz;E. Fox;C. Morton;B. Vallée
通讯作者：
B. Vallée
DOI：
--
发表时间：
1995
期刊：
Medicine and science in sports and exercise.
影响因子：
--
作者：
Bouchard,C;Leon,AS;Rao,DC;Skinner,JS;Wilmore,JH;Gagnon,J
通讯作者：
Gagnon,J
影响因子：
2.9
作者：
STRYDOM, DJ;FETT, JW;VALLEE, BL
通讯作者：
VALLEE, BL
影响因子：
3.1
作者：
Adams, JM
通讯作者：
Adams, JM
高血压：种族差异。
DOI：
--
发表时间：
1990
期刊：
影响因子：
--
作者：
Eisner Gm
通讯作者：
Eisner Gm