Severity of rhinovirus infection in hospitalized adults is unrelated to genotype.
Severity of rhinovirus infection in hospitalized adults is unrelated to genotype.
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DOI：
10.1309/ajcphikrjc67aazj
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发表时间：
2014-08
影响因子：
3.5
通讯作者：
Kraft CS
中科院分区：
文献类型：
--
作者：
McCulloch DJ;Sears MH;Jacob JT;Lyon GM;Burd EM;Caliendo AM;Hill CE;Nix WA;Oberste MS;Kraft CS
确定鼻病毒（RV）种类是否与成人更严重的临床疾病相关。通过VP4基因和VP2基因5′端区域的逆转录聚合酶链反应，对72份成人呼吸道病毒阳性样本进行测序和系统发育分析。比较不同RV种类的临床特征和疾病严重程度。系统发育分析确定了三个不同的类群，分别为RV-A（54%）、B（11%）和C（35%）种。在未经调整的模型中，感染RV-B的患者明显更有可能出现死亡或重症监护病房入院的复合结局变量（P = 0.03），但在控制患者性别时，这种影响减弱。当控制患者性别时，RV种类与不良结局之间关系的逻辑模型产生了不显著的优势比。在我们的成年人群中，感染RV-A或RV-B与更严重的疾病有关；然而，在控制混杂因素后，这种关联消失了。
To determine whether rhinovirus (RV) species is associated with more severe clinical illness in adults. Seventy-two RV-positive viral respiratory samples from adult patients were sequenced and analyzed phylogenetically after reverse transcriptase polymerase chain reaction of the region spanning the VP4 gene and 5′ terminus of the VP2 gene. The clinical features and severity of illness associated with the different RV species were compared. Phylogenetic analysis identified three distinct clusters as RV-A (54%), B (11%), or C (35%) species. In an unadjusted model, patients with RV-B infection were significantly more likely to have the composite outcome variable of death or intensive care unit admission (P = .03), but this effect diminished when controlling for patient sex. A logistic model of the relationship between RV species and adverse outcomes produced nonsignificant odds ratios when controlling for patient sex. Infection with RV-A or RV-B was associated with greater severity of illness in our adult population; however, the association disappeared after controlling for confounders.