Association of Obstructive Sleep Apnea Risk With Asthma Control in Adults
Association of Obstructive Sleep Apnea Risk With Asthma Control in Adults
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DOI：
10.1378/chest.09-3066
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发表时间：
2010-09-01
期刊：
影响因子：
9.6
通讯作者：
Jarjour, Nizar N.
中科院分区：
文献类型：
--
作者：
Teodorescu, Mihaela;Polomis, David A.;Jarjour, Nizar N.
背景：未被识别的阻塞性睡眠呼吸暂停（OSA）可能导致哮喘控制不佳，尽管有最佳的治疗。我们的目的是评估OSA的风险和哮喘控制之间的关系在adultes.Methods：哮喘患者在三级保健诊所就诊时，经常看到完成了验证的睡眠呼吸暂停量表的睡眠障碍问卷（SA-SDQ）和哮喘控制问卷（ACQ）。ACQ评分>= 1.5定义为哮喘控制不佳，SA-SDQ评分男性>= 36，女性>= 32定义为OSA高风险。Logistic回归模型的高OSA风险与控制不佳的哮喘（ACQ完整版和简短版本）。结果：在472例哮喘受试者中，平均+/- SD ACQ（完整版）评分为0.87 +/- 0.90，80（17%）例受试者控制不佳。平均SA-SDQ评分为27 +/- 7，109例（23%）受试者符合OSA高风险定义。在调整肥胖和其他已知会恶化哮喘控制的因素后，平均而言，高OSA风险与哮喘控制不佳的几率高出2.87倍（ACQ完整版）（95%CI，1.54-5.32; P = .0009）。类似的独立协会时，看到使用短ACQ versions.Conclusions：高OSA的风险显着相关的控制不好的哮喘独立的已知的哮喘发作者，无论使用的ACQ版本。对于难以充分控制哮喘的患者，应进行OSA筛查。胸部2010; 138（3）：543-550
Background: Unrecognized obstructive sleep apnea (OSA) may lead to poor asthma control despite optimal therapy. Our objective was to evaluate the relationship between OSA risk and asthma control in adults.Methods: Patients with asthma seen routinely at tertiary-care clinic visits completed the validated Sleep Apnea Scale of the Sleep Disorders Questionnaire (SA-SDQ) and Asthma Control Questionnaire (ACQ). An ACQ score of >= 1.5 defined not-well-controlled asthma, and an SA-SDQ score of >= 36 for men and >= 32 for women defined high OSA risk. Logistic regression was used to model associations of high OSA risk with not-well-controlled asthma (ACQ full version and short versions).Results: Among 472 subjects with asthma, the mean +/- SD ACQ (full version) score was 0.87 +/- 0.90, and 80 (17%) subjects were not well controlled. Mean SA-SDQ score was 27 +/- 7, and 109 (23%) subjects met the definition of high OSA risk. High OSA risk was associated, on average, with 2.87-times higher odds for not-well-controlled asthma (ACQ full version) (95% CI, 1.54-5.32; P = .0009) after adjusting for obesity and other factors known to worsen asthma control. Similar independent associations were seen when using the short ACQ versions.Conclusions: High OSA risk is significantly associated with not-well-controlled asthma independent of known asthma aggravators and regardless of the ACQ version used. Patients who have difficulty achieving adequate asthma control should be screened for OSA. CHEST 2010; 138(3):543-550