EFFECT OF ACHYLIA GASTRICA ON IRON ABSORPTION
EFFECT OF ACHYLIA GASTRICA ON IRON ABSORPTION
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DOI：
10.1172/jci105002
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发表时间：
1964-01-01
影响因子：
15.9
通讯作者：
VALBERG, LS
中科院分区：
文献类型：
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作者：
COOK, JD;BROWN, GM;VALBERG, LS
鉴于胃分泌在铁吸收中的重要性的相互矛盾的报道，调查了9名胃无肌症患者和9名对照者从低铁含量的白色面包试验餐中吸收放射性铁的情况。缺铁组平均铁吸收率为19.8%，对照组为35.2%。平均值之间的差异在1%的水平上是显著的。当给予正常胃液和试验剂量的食物铁时，无环组的吸收显著增加。尽管在试验剂量中加入中和胃液的影响略有不同，但平均吸收率显著低于正常胃液，与单独使用面包的吸收率无差异。结果表明，在没有胃液分泌的情况下，从低铁含量的面包试验餐中吸收的铁减少，并且正常胃液而不是中和胃液的给药纠正了该缺陷。
In view of the conflicting reports of the importance of gastric secretion in Fe absorption an investigation was made of the absorption of radioiron from a test meal of white bread of low Fe content in 9 patients with achylia gastrica and 9 control subjects. The mean Fe absorption was 19.8% in the achylic group and 35.2% in the controls. The difference between the means was significant at the 1% level. A significant increase in absorption occurred in the achylic group when normal gastric juice was given with the test dose of food Fe. Although the effect of adding neutralized gastric juice to the test dose was somewhat variable, the mean absorption was significantly lower than with normal gastric juice and not different from the absorption with bread alone. The results indicate that the absorption of Fe from a test meal of bread of low Fe content is diminished in the absence of gastric secretion and that the administration of normal gastric juice but not of neutralized gastric juice corrects the defect.