Distinct seasonal patterns in the onset of adult idiopathic inflammatory myopathy in patients with anti-Jo-1 and anti-signal recognition particle autoantibodies.
Distinct seasonal patterns in the onset of adult idiopathic inflammatory myopathy in patients with anti-Jo-1 and anti-signal recognition particle autoantibodies.
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具有抗 Jo-1 和抗信号识别颗粒自身抗体的成人特发性炎症性肌病发病的明显季节性模式。
DOI：
10.1002/art.1780341108
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发表时间：
1991
影响因子：
--
通讯作者：
Plotz,PH
中科院分区：
文献类型：
--
作者：
Leff,RL;Burgess,SH;Miller,FW;Love,LA;Targoff,IN;Dalakas,MC;Joffe,MM;Plotz,PH
在特发性炎性肌病（IIM;或多发性肌炎/皮肌炎）中，肌炎特异性自身抗体抗Jo-1和抗信号识别颗粒（抗SRP）似乎定义了临床和免疫遗传学上不同的患者组。我们发现，在抗Jo-1自身抗体患者（平均4月，P< 0.02）和抗SRP自身抗体患者（平均11月，P <0.02）中，虚弱发作的月份不是随机的;两组患者都经历了疾病的快速发作。相比之下，传统分类的多发性肌炎和皮肌炎患者没有可识别的季节性模式，发病率也没有差异。这些发现表明，搜索以疾病特异性自身抗体为特征的自身免疫性疾病发作的季节性模式可能为病因学提供有用的线索。
In idiopathic inflammatory myopathy (IIM; or, polymyositis/dermatomyositis), the myositis‐specific autoantibodies anti‐Jo‐1 and anti‐signal recognition particle (anti‐SRP), appear to define clinically and immunogenetically distinct groups of patients. We show here that the month during which the onset of weakness occurs is not random in patients with anti‐Jo‐1 autoantibodies (average month April,P< 0.02) and in those with anti‐SRP autoantibodies (average month November,P< 0.02); both groups of patients also experience rapid onset of disease. By contrast, patients classified into the traditional categories of polymyositis and dermatomyositis do not have recognizable seasonal patterns and do not differ in the rate of onset of disease. These findings suggest that searches for seasonal patterns in the onset of autoimmune disorders characterized by disease‐specific autoantibodies may provide useful clues to etiology.