Rotating night shift work and risk of ovarian cancer.
Rotating night shift work and risk of ovarian cancer.
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DOI：
10.1158/1055-9965.epi-11-0138
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发表时间：
2011-05
期刊：
影响因子：
--
通讯作者：
Tworoger SS
中科院分区：
文献类型：
--
作者：
Poole EM;Schernhammer ES;Tworoger SS
夜班工作与乳腺癌和子宫内膜癌的较高风险有关，但很少有研究评估其与其他生殖系统癌症的关联。我们对参加护士健康研究 (NHS) 和 NHSII 两项大型队列研究的 181,548 名女性进行了 20 年的随访，研究了夜班轮班工作与卵巢癌风险之间的关联。 NHS 于 1988 年查询了夜班轮班工作的年数，NHSII 于 1989 年、1991 年、1993 年、2001 年和 2005 年查询了夜班轮班工作的年数。我们使用 Cox 比例风险回归来模拟每个轮班工作类别（1-2 年、3-5 年、6-9 年、10-14 年、15-19 年和 20 年以上）的卵巢癌风险比 (HR) 和 95% 置信区间 (CI)。我们在 2,974,672 人年的随访中确认了 718 例卵巢癌病例。在这两个队列中，轮班工作与卵巢癌风险均无关。结合这两个队列，与没有任何夜班工作的女性相比，15-19 年夜班轮班工作的 HR 为 1.28（95% CI：0.84-1.94），20 年以上为 0.80（95% CI：0.51-1.23）。在这项大型前瞻性研究中，夜班轮班时间与卵巢癌风险之间没有关联。尽管夜班工作与其他癌症有关，但似乎与卵巢癌风险增加无关。然而，有必要进一步探索褪黑激素与卵巢癌风险之间的关联。
Night shift work has been associated with higher risks of breast and endometrial cancer, but few studies have evaluated associations with other reproductive cancers. We examined the association between rotating night shift work and risk of ovarian cancer during 20 years of follow-up in 181,548 women participating in two large cohort studies, the Nurses’ Health Study (NHS) and NHSII. Number of years of rotating night shift work was queried in 1988 for NHS and in 1989, 1991, 1993, 2001, and 2005 for NHSII. We used Cox proportional hazards regression to model hazard ratios (HRs) and 95% confidence intervals (CI) of ovarian cancer for each shift work category (1-2 years, 3-5 years, 6-9 years, 10-14 years, 15-19 years, and 20+ years). We confirmed 718 incident cases of ovarian cancer over 2,974,672 person-years of follow-up. Rotating shift work was not associated with ovarian cancer risk in either cohort individually. Combining both cohorts, compared to women without any night work, the HR for 15-19 years of rotating night shift work was 1.28 (95% CI: 0.84-1.94), and for 20+ years 0.80 (95% CI: 0.51-1.23). In this large prospective study, there was no association between duration of rotating night shift work and risk of ovarian cancer. Although associated with other cancers, night shift work does not appear to be associated with increased risk of ovarian cancer. However, further exploration of the association between melatonin and risk of ovarian cancer is warranted.