The effect of current used bone substitution materials and platelet-rich plasma on periosteal cells by ectopic site implantation: An in-vivo pilot study
The effect of current used bone substitution materials and platelet-rich plasma on periosteal cells by ectopic site implantation: An in-vivo pilot study
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DOI：
10.1016/j.jcms.2011.07.012
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发表时间：
2012-07-01
影响因子：
3.1
通讯作者：
Schlegel, Karl Andreas
中科院分区：
文献类型：
--
作者：
Metzler, Philipp;von Wilmowsky, Cornelius;Schlegel, Karl Andreas
本研究的目的是研究异位植入骨膜覆盖的骨替代物后，在使用和不使用自体富含血小板血浆(PRP)的情况下新生骨的形成。在35只小型猪皮下植入不同的骨替代物(牛羟基磷灰石(BHAP)、植入性羟基磷灰石(PHAP)和生物玻璃(BG))24周后，对其骨再生率进行了显微放射学和组织学比较。在不加PRP的情况下，bHAP显示出平均32.41%+/-29.99%的新骨形成，而其他替代材料没有检测到矿化。结合PRP，bHAP(63.61%+/-12.98：P+/-0.03)和PHAP(34.37+/-29.38；P+/-0.015)组新生骨形成明显高于无PRR组，BG组未见骨化。结论：bHAP和PHAP骨替代物与PRP联合应用对异位、皮下、低血管部位植入后新生骨形成的骨膜细胞有显著促进作用。(C)2011年欧洲颅颌面部外科协会。
The aim of this study was to investigate de novo bone formation following ectopic site implantation of bone substitutes covered by periosteum, with and without the application of autologous platelet-rich plasma (PRP). Twenty-four weeks after subcutaneous implantation of various bone substitutes (bovine hydroxyapatite (bHAP), phycogenic hydroxyapatite (pHAP), and bioglass (BG)) in 35 mini-pigs, bone regeneration rates were compared microradiographically and histologically. Without PRP, bHAP showed a mean de novo bone formation of 32.41% +/- 29.99, in contrast to the other substitute materials where no mineralization could be detected. In combination with PRP, in the bHAP (63.61% +/- 12.98: p +/- 0.03) and pHAP (34.37 +/- 29.38; p +/- 0.015) group, significantly higher de novo bone formation was ascertained than without PRR No ossification could be detected in the BG group. In conclusion, bHAP and pHAP bone substitutes in combination with PRP showed a significant positive effect on periosteal cells by de novo bone formation after ectopic, subcutaneous, low-vascular site implantation. (C) 2011 European Association for Cranio-Maxillo-Facial Surgery.