Identifying common genome-wide risk genes for major psychiatric traits
Identifying common genome-wide risk genes for major psychiatric traits
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识别主要精神特征的常见全基因组风险基因
DOI：
10.1007/s00439-019-02096-4
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发表时间：
2020-02-01
期刊：
影响因子：
5.3
通讯作者：
Zhang, Fuquan
中科院分区：
文献类型：
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作者：
Liu, Sha;Rao, Shuquan;Zhang, Fuquan
主要的精神特征在基因上是相互关联的，但哪些基因在不同的特征中起多效性作用尚不清楚。我们整理并比较了从大规模全基因组关联研究中鉴定出的七种精神特征的基因，包括抑郁症、双相情感障碍、精神分裂症、自闭症谱系障碍、注意力缺陷/多动障碍、焦虑和神经质。然后探讨了顶端多效基因的生物学功能。7个性状共鉴定出243个交叉性状基因。除自闭症谱系障碍外，这些精神特征的重叠基因显著富集。染色体5q14.3、11q23.2和7p22.3是对这些精神特征具有最高多效性的三个基因组区域。长非编码基因inc00461对5个精神性状的多效性最高。计算机和小鼠功能研究支持LINC00461在神经发育中的重要作用。总之，我们的研究为主要精神特征之间的共同遗传责任提供了见解。
Major psychiatric traits are genetically inter-correlated with one another, but it not well known which genes play pleiotropic effects across different traits. We curated and compared genes identified from large-scale genome-wide association studies for seven psychiatric traits, including depression, bipolar disorder, schizophrenia, autism spectrum disorder, attention-deficit/hyperactivity disorder, anxiety and neuroticism. We then explored biological functions of the top pleiotropic genes. A total of 243 cross-trait genes were identified for the seven traits. Except for autism spectrum disorder, there was significant enrichment of overlapped genes across these psychiatric traits. Chromosome 5q14.3, 11q23.2, and 7p22.3 are the three genomic regions conferring highest pleiotropic effects for these psychiatric traits. The long non-coding geneLINC00461showed the highest pleiotropic effects on five psychiatric traits. In silico and functional studies with mice support the vital role of LINC00461 in neurodevelopment. In sum, our study provides insights into the shared genetic liability among major psychiatric traits.