Automated Segmentation of the Cup and Rim from Spectral Domain OCT of the Optic Nerve Head
Automated Segmentation of the Cup and Rim from Spectral Domain OCT of the Optic Nerve Head
复制标题
DOI：
10.1167/iovs.09-3790
复制
发表时间：
2009-12-01
影响因子：
4.4
通讯作者：
Kwon, Young H.
中科院分区：
文献类型：
--
作者：
Abramoff, Michael D.;Lee, Kyungmoo;Kwon, Young H.
目的.评价从视神经乳头（ONH）的接近各向同性的光谱域（SD）OCT图像确定杯和边缘的自动算法的性能，并与青光眼专家从同一只眼睛的立体彩色照片确定的杯和边缘进行比较。34例连续青光眼患者被纳入研究，并在同一天用SD-OCT和立体彩色摄影对左眼ONH进行成像。通过一种新的体素列分类算法在所有ONH OCT体积中分割杯和边缘，并确定线性杯盘（c/d）比。三位受训的青光眼专家对立体彩色照片进行了面积测量，并确定了c/d。主要的结果测量是算法确定的c/d和平面测量得出的c/d之间的相关性。算法c/d与专家1、2和3的相关性分别为0.90、0.87和0.93。专家1：2、1：3、2：3的c/d相关系数分别为0.89、0.93、0.88。在这项初步研究中，我们开发了一种新的算法，以确定在接近各向同性的SD-OCT图像的ONH杯和边缘，并已表明，其性能确定的杯和边缘从SD-OCT图像是类似的面积由青光眼专家。验证更大的青光眼样本以及正常对照是必要的。（Invest Ophthalmol维斯科学。2009; 50：5778-5784）DOI：10.1167/iovs.09-3790
PURPOSE. To evaluate the performance of an automated algorithm for determination of the cup and rim from close-to-isotropic spectral domain (SD) OCT images of the optic nerve head (ONH) and compare to the cup and rim as determined by glaucoma experts from stereo color photographs of the same eye.METHODS. Thirty-four consecutive patients with glaucoma were included in the study, and the ONH in the left eye was imaged with SD-OCT and stereo color photography on the same day. The cup and rim were segmented in all ONH OCT volumes by a novel voxel column classification algorithm, and linear cup-to-disc (c/d) ratio was determined. Three fellowship-trained glaucoma specialists performed planimetry on the stereo color photographs, and c/d was also determined. The primary outcome measure was the correlation between algorithm-determined c/d and planimetry-derived c/d.RESULTS. The correlation of algorithm c/d to experts 1, 2, and 3 was 0.90, 0.87, and 0.93, respectively. The c/d correlation of expert 1 to 2, 1 to 3, and 2 to 3, were 0.89, 0.93, and 0.88, respectively.CONCLUSIONS. In this preliminary study, we have developed a novel algorithm to determine the cup and rim in close-to-isotropic SD-OCT images of the ONH and have shown that its performance for determination of the cup and rim from SD-OCT images is similar to that of planimetry by glaucoma experts. Validation on a larger glaucoma sample as well as normal controls is warranted. (Invest Ophthalmol Vis Sci. 2009; 50: 5778-5784) DOI:10.1167/iovs.09-3790