Statistical issues in gene association studies.
Statistical issues in gene association studies.
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DOI：
10.1007/978-1-61737-954-3_2
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发表时间：
2011
影响因子：
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通讯作者：
R. Watanabe
中科院分区：
文献类型：
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作者：
R. Watanabe
本章回顾与基因关联研究相关的统计问题。目标是为不具备广泛统计背景的个人回顾研究设计和分析的各个方面。我们将回顾与全基因组和候选基因研究相关的统计问题。审查的主题包括研究设计、功效和样本量、数据检查、统计方法、人群分层和多重测试。我们从 2 型糖尿病遗传学文献中抽取例子来说明所讨论的一些问题。
This chapter reviews statistical issues related to gene association studies. The goal is to review various aspects of study design and analysis for individuals who do not have an extensive statistical background. We will review statistical issues as they relate to both genome-wide and candidate gene studies. Topics reviewed include study design, power and sample size, data checking, statistical methods, population stratification, and multiple testing. We draw examples from the type 2 diabetes genetics literature to illustrate some of the issues discussed.