Computational fluid dynamics for investigation of saliva pressure in parotid obstruction
Computational fluid dynamics for investigation of saliva pressure in parotid obstruction
复制标题
用于研究腮腺阻塞唾液压力的计算流体动力学
DOI：
10.1002/lary.23226
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发表时间：
2012-05-01
期刊：
影响因子：
2.6
通讯作者：
Zhang, Zhiguang
中科院分区：
文献类型：
--
作者：
Xu, Yue;Zhou, Wenyan;Zhang, Zhiguang
目标/假设：腮腺阻塞是影响腮腺的最常见问题之一。我们的目的是利用计算流体动力学研究 Stensen 导管的阻塞率 (BR) 和导管内压力变化。研究设计：回顾性分析 2009 年至 2011 年因腮腺梗阻接受介入性唾液腺内窥镜检查的 16 例患者。方法：根据计算机断层扫描 (CT) 唾液图像重建 Stensen 导管的三维结构。采用腮腺阻塞流体动力学的有限体积模型来分析休息和刺激条件下的压力分布。结果：导管内压力随着距孔口距离的增加而增加。同一 BR 中上游压力高于下游压力 (P < .05)。上游压力随着BR的增加而增加。据统计，当BR达到60%时，表明压力转折点。只有当BR远大于90%时，压力才达到811.64 Pa，此时患者在休息状态下会感到疼痛肿胀。在刺激条件下，当BR从80%增加到90%时，上游压力从无阻塞状态的1.3倍增加到2.9倍，这可能会加重阻塞症状。相同条件下下游压力无显着性差异（P > .05）。结论：CT唾液造影可有效分析腮腺梗阻患者导管内压力分布。对斯坦森管中唾液流体动力学的分析可能为阻塞性疾病提供进一步的病理生理学机制。
Objectives/Hyothesis: Parotid obstruction is one of the most common problems affecting the parotid gland. We aimed to investigate the blockage ratio (BR) and the intraductal pressure change of Stensen's duct using computational fluid dynamics.Study Design: Retrospective review of 16 patients who had undergone interventional sialendoscopy for parotid obstruction from 2009 to 2011.Methods: The three-dimensional configurations of Stensen's duct were reconstructed from computed tomography (CT) sialographic images. Finite volume modeling in fluid dynamics of parotid obstruction was used to analyze the pressure distribution under conditions of rest and stimulation.Results: Intraductal pressure increased with increasing distance from the orifice. The upstream pressure was higher than that of downstream pressure in the same BR (P < .05). The upstream pressure increased as the BR increased. Statistically, the pressure turning point was indicated when BR 60%. Only when the BR was much greater than 90% did the pressure reach 811.64 Pa, at which point patients could feel the painful swelling under the rest condition. Under the stimulated condition, the upstream pressure increased from 1.3- to 2.9-fold of that of the no blocking state when the BR increased from 80% to 90%, which may aggravate the obstructive symptoms. There was no significant difference observed for downstream pressure under the same condition (P > .05).Conclusions: CT sialography was effectively used for analysis of the intraductal pressure distribution in patients with parotid obstruction. Analysis of salivary fluid dynamics in Stensen's duct may provide a further pathophysiological mechanism for obstructive diseases.