Integrin-collagen complex: a metal-glutamate handshake
Integrin-collagen complex: a metal-glutamate handshake
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DOI：
10.1016/s0969-2126(00)00153-2
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发表时间：
2000-06-15
期刊：
影响因子：
5.7
通讯作者：
Berman, HM
中科院分区：
文献类型：
--
作者：
Bella, J;Berman, HM
最近确定的晶体结构的整合素I结构域和合成的胶原蛋白肽之间的复合物显示胶原蛋白三螺旋从事特定的大分子识别和结合。这种结构证实了先前提出的整合素I结构域的结合机制，并对整合素活化和信号传导具有重要意义。
The recently determined crystal structure of the complex between an integrin I domain and a synthetic collagen peptide shows a collagen triple-helix engaged in specific macromolecular recognition and binding. This structure confirms a previously proposed binding mechanism for integrin I domains and has important implications for integrin activation and signalling.