Overexpression of long non-coding RNA H19 is associated with unfavorable prognosis in patients with colorectal cancer and increased proliferation and migration in colon cancer cells
Overexpression of long non-coding RNA H19 is associated with unfavorable prognosis in patients with colorectal cancer and increased proliferation and migration in colon cancer cells
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DOI：
10.3892/ol.2017.6390
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发表时间：
2017-08-01
期刊：
影响因子：
2.9
通讯作者：
Wang, Peng-Yuan
中科院分区：
文献类型：
--
作者：
Chen, Shan-Wen;Zhu, Jing;Wang, Peng-Yuan
长非编码RNA印记母体表达转录物（非蛋白质编码）（H19）先前已被鉴定与多种癌症的发生有关。然而，H19在结直肠癌发病机制中的功能仍不清楚。本研究调查了结直肠肿瘤组织中 H19 的表达水平，以及 H19 表达与临床病理学变量和预后之间的关联。此外，在 HCT-116 和 SW-480 细胞中研究了 H19 过表达对结肠癌细胞活力、迁移和上皮间质转化 (EMT) 的影响。本研究的结果表明，H19 的过度表达与结直肠癌患者的无复发生存率和总生存率降低以及结肠癌细胞的活力和迁移增加有关。 EMT 过程的诱导可能是与 H19 诱导的结肠癌细胞转移潜力增加相关的潜在分子机制。
Long non-coding RNA-imprinted maternally expressed transcript (non-protein coding) (H19) has been previously identified to be involved in the development of a number of types of cancer. However, the function of H19 in the pathogenesis of colorectal cancer remains unclear. The expression level of H19 in colorectal tumor tissues, and the association between H19 expression and clinicopathological variables and prognosis was investigated in the present study. In addition, the effect of H19 overexpression on viability, migration and epithelial-mesenchymal transition (EMT) of colon cancer cells was investigated in HCT-116 and SW-480 cells. The results of the present study suggest that overexpression of H19 is associated with decreased recurrence-free survival and overall survival rates in patients with colorectal cancer, and increased viability and migration in colon cancer cells. The induction of the EMT process may be an underlying molecular mechanism associated with the H19-induced increased metastasis potential of colon cancer cells.