ENDOTOXIN, CEREBRAL BLOOD-FLOW, AMINO-ACIDS AND BRAIN-DAMAGE IN YOUNG-RABBITS
ENDOTOXIN, CEREBRAL BLOOD-FLOW, AMINO-ACIDS AND BRAIN-DAMAGE IN YOUNG-RABBITS
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DOI：
10.1016/s0387-7604(88)80094-9
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发表时间：
1988-01-01
影响因子：
1.7
通讯作者：
MITO, T
中科院分区：
文献类型：
--
作者：
ANDO, M;TAKASHIMA, S;MITO, T
研究了细菌内毒素（脂多糖；LPS）对幼兔脑血流量（CBF）、氨基酸水平和脑组织学的影响。 LPS给药后10分钟和120分钟，大脑皮质的CBF略有下降，而大脑白质的CBF明显下降。组织学检查显示24小时时小血管周围仅有轻微固缩的神经元，72小时时深部大脑皮层和白质出现多灶性坏死。 给予LPS后24小时，血浆和脑区的一些氨基酸增加，其中大部分是必需氨基酸。 24小时时脑白质中的GABA减少，72小时时大部分非必需氨基酸和生糖氨基酸减少。这些结果表明脑组织学变化主要与脑内灌注不足和血管损伤有关。氨基酸的变化也可能与脑细胞损伤相关的氨基酸代谢不当有关。
The effects of bacterial endotoxin (lipopolysaccharide; LPS) on the cerebral blood flow (CBF), amino acid levels and brain histology were studied in young rabbits. The CBF was slightly decreased in the cerebral cortex and markedly decreased in the cerebral white matter at 10 and 120 minutes after LPS administration. Histological examination revealed only slightly pyknotic neurons around small vessels at 24 hours, and multifocal necrosis in the deep cerebral cortex and white matter at 72 hours. Some amino acids were increased in the plasma and brain regions at 24 hours after LPS administration, most of which were essential amino acids. GABA in the cerebral white matter was decreased at 24 hours, At 72 hours, most non-essential and glucogenic amino acids were decreased. These results suggest that the brain histological changes are related mainly to hypoperfusion and vascular damage in the brain. The amino acid changes may also be related to inappropriate amino acid metabolism associated with brain cell damage.