Multioscillatory Circadian Organization in a Vertebrate, Iguana iguana
Multioscillatory Circadian Organization in a Vertebrate, Iguana iguana
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脊椎动物鬣蜥的多振荡昼夜节律组织
DOI：
10.1523/jneurosci.18-03-01105.1998
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发表时间：
1998
期刊：
影响因子：
--
通讯作者：
M. Menaker
中科院分区：
文献类型：
--
作者：
G. Tosini;M. Menaker
蜥蜴鬣蜥在恒定的环境温度下表现出内源性的体温昼夜节律和运动活动。虽然手术切除顶眼对明显的昼夜节律只有轻微的影响，但随后的松果体切除术完全消除了体温的节律。然而，运动活动的节奏仅轻微影响顶骨切除术加松果体切除术。我们的研究结果表明，松果体复合体主要参与体温昼夜节律的产生和控制，但仅少量参与运动节律。血浆褪黑激素水平不显着降低顶骨切除术，而松果体切除术显著降低水平，并完全消除褪黑激素在循环中的昼夜节律。分离的顶骨眼、松果体和视网膜在培养中维持≥4 d时都能合成具有强烈昼夜节律性的褪黑激素，尽管在完整的动物中，所有或几乎所有循环的褪黑激素都来自松果体。鬣蜥的昼夜节律系统是由多个昼夜节律振荡器组成的，这些振荡器存在于不同的组织中，具有特定的不同作用。
The lizard Iguana iguana when kept in constant ambient temperature displays endogenously generated circadian rhythms of body temperature and locomotor activity. Although surgical removal of the parietal eye has only slight effects on overt circadian rhythmicity, subsequent pinealectomy completely abolishes the rhythm of body temperature. However, the rhythm of locomotor activity is only slightly affected by parietalectomy plus pinealectomy. Our results demonstrate that the pineal complex is centrally involved in the generation and control of the circadian rhythm of body temperature but is only marginally involved in locomotor rhythmicity. Plasma melatonin levels are not significantly reduced by parietalectomy, whereas pinealectomy dramatically lowers the level and completely eliminates the circadian rhythm of melatonin in the circulation. Isolated parietal eye, pineal, and retina all synthesize melatonin with robust circadian rhythmicity when maintained for ≥4 d in culture, although in the intact animal all or almost all of the circulating melatonin comes from the pineal. The circadian system of I. iguana is composed of multiple circadian oscillators that reside in different tissues and have specific and different roles.
鸟类松果体，昼夜节律振荡器的脊椎动物模型系统：通过光、第二信使和大分子合成对昼夜节律进行细胞调节。
DOI：
10.1016/b978-0-12-571145-6.50010-8
发表时间：
1989
期刊：
Recent progress in hormone research
影响因子：
--
作者：
Takahashi,JS;Murakami,N;Nikaido,SS;Pratt,BL;Robertson,LM
通讯作者：
Robertson,LM