Circulating resistin levels are not associated with fat redistribution, insulin resistance, or metabolic profile in patients with the highly active antiretroviral therapy-induced metabolic syndrome
Circulating resistin levels are not associated with fat redistribution, insulin resistance, or metabolic profile in patients with the highly active antiretroviral therapy-induced metabolic syndrome
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DOI：
10.1210/jc.2005-0742
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发表时间：
2005-09-01
影响因子：
5.8
通讯作者：
Mantzoros, CS
中科院分区：
文献类型：
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作者：
Barb, D;Wadhwa, SG;Mantzoros, CS
背景：高效抗逆转录病毒疗法(HAART)诱导的代谢综合征的发生机制尚不完全清楚。目的：本研究的目的是探讨脂肪细胞分泌的激素抵抗素是否与HAART诱导的代谢综合征的人体测量和代谢异常有关。设计、地点和患者：我们对227名HIV阳性患者(37名女性和190名男性)进行了横断面研究。根据病史、体格检查、双能X线骨密度仪和单层CT将患者分为4组：非脂肪再分布组85例，脂肪堆积组42例，脂肪消失组35例，混合性脂肪再分布组56例。主要观察指标：主要观察指标为血清抵抗素水平、人体测量学和代谢变量。结果：脂肪堆积、脂肪消退、混合脂肪再分布组与非脂肪再分布组之间血清抵抗素水平差异无统计学意义。抵抗素与体脂百分比(r=0.20；P=0.01)、四肢总脂肪(r=0.18；P<；0.01)、腹部皮脂(r=0.19；P=0.01)呈微弱但显著的正相关，而与腹部内脏脂肪(r=-0.10；P=0.16)或腰臀比(r=-0.05；P=0.43)无关。在调整性别(女性3.92±2.71 ng/ml；男性2.96±2.61 ng/ml；P=0.05)后，抵抗素与上述指标的相关性不再显著。重要的是，抵抗素水平与空腹血糖、胰岛素、稳态模型胰岛素抵抗指数、甘油三酯或胆固醇水平无相关性。结论：抵抗素与性别有关，但不太可能在HAART诱导的代谢综合征的胰岛素抵抗和代谢异常中起主要作用。
Context: The mechanisms underlying the development of the highly active antiretroviral therapy ( HAART)-induced metabolic syndrome remain to be fully elucidated.Objective: The objective of this study was to investigate whether the adipocyte-secreted hormone, resistin, is associated with anthropometric and metabolic abnormalities of the HAART-induced metabolic syndrome.Design, Setting, and Patients: We conducted a cross-sectional study of 227 HIV-positive patients (37 women and 190 men) recruited from the infectious diseases clinics. On the basis of history, physical examination, dual-energy x-ray absorptiometry, and single-slice computed tomography, patients were classified into four groups: non-fat redistribution (n = 85), fat accumulation (n = 42), fat wasting (n = 35), and mixed fat redistribution (n = 56).Main Outcome Measures: The main outcome measures were serum resistin levels and anthropometric and metabolic variables.Results: Mean serum resistin levels were not significantly different among subjects with fat accumulation, fat wasting, or mixed fat redistribution or between these groups and the non-fat redistribution group. We found a weak, but significant, positive correlation between resistin and percent total body fat (r = 0.20; P = 0.01), total extremity fat (r = 0.18; P < 0.01), and abdominal sc fat (r = 0.19; P = 0.01), but not abdominal visceral fat (r = -0.10; P = 0.16) or waist to hip ratio (r = -0.05; P = 0.43). When adjustments were made for gender (women, 3.92 +/- 2.71 ng/ml; men, 2.96 +/- 2.61 ng/ml; P = 0.05), correlations between resistin and the above parameters were no longer significant. Importantly, resistin levels were not correlated with fasting glucose, insulin, homeostasis model assessment of insulin resistance index, triglycerides, or cholesterol levels in the whole group.Conclusions: Resistin is related to gender, but is unlikely to play a major role in the insulin resistance and metabolic abnormalities of the HAART-induced metabolic syndrome.