A small number of open Ca2+ channels trigger transmitter release at a central GABAergic synapse
A small number of open Ca2+ channels trigger transmitter release at a central GABAergic synapse
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DOI：
10.1038/nn.2461
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发表时间：
2010-01-01
影响因子：
25
通讯作者：
Jonas, Peter
中科院分区：
文献类型：
--
作者：
Bucurenciu, Iancu;Bischofberger, Josef;Jonas, Peter
为了确定大鼠海马抑制性篮细胞-颗粒细胞突触中释放递质所需的开放Ca2+通道的数量，我们结合了突触前Ca2+成像、突触后电流记录和建模。我们发现打开三个或更少的Ca2+通道触发递质释放。此外，尽管Ca2+通道开放是随机的，但少数Ca2+通道能够以高时间精度唤起释放。
To determine the number of open Ca2+ channels necessary for transmitter release at the inhibitory basket cell-granule cell synapse in rat hippocampus, we combined presynaptic Ca2+ imaging, recording of postsynaptic currents and modeling. We found that that the opening of three or fewer Ca2+ channels triggered transmitter release. Furthermore, a small number of Ca2+ channels were able to evoke release with high temporal precision, despite stochastic Ca2+ channel opening.