Microglia Fighting for Neurological and Mental Health: On the Central Nervous System Frontline of COVID-19 Pandemic.
Microglia Fighting for Neurological and Mental Health: On the Central Nervous System Frontline of COVID-19 Pandemic.
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小胶质细胞为神经和心理健康而战：在COVID-19大流行的中枢神经系统前线。
DOI：
10.3389/fncel.2021.647378
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发表时间：
2021
影响因子：
5.3
通讯作者：
Tremblay MÈ
中科院分区：
文献类型：
--
作者：
Gonçalves de Andrade E;Šimončičová E;Carrier M;Vecchiarelli HA;Robert MÈ;Tremblay MÈ
2019年冠状病毒病(新冠肺炎)以心肺改变为特征，越来越多的报告还表明感染者出现神经和精神症状。在新冠肺炎病理过程中，中枢神经系统可能受到严重急性呼吸综合征冠状病毒2(SARS-CoV-2)的直接入侵、全身炎症反应过度或缺氧的影响。大流行造成的心理社会压力进一步影响新冠肺炎患者的中枢神经系统，也影响未感染的人群，可能导致各种神经或精神健康障碍的出现或加剧。小胶质细胞是中枢神经系统内稳态维持和炎症反应的中心角色，与其他中枢神经系统细胞协同发挥其重要功能。在动态平衡对脑实质的挑战中，小胶质细胞改变其密度、形态和分子特征，导致其功能的调整。在这篇综述中，我们讨论了小胶质细胞如何参与对来自新冠肺炎的中枢神经系统侮辱的神经保护和神经毒性反应。我们研究了这些反应如何解释，至少部分解释了新冠肺炎患者和普通人群中报告的神经和精神表现。此外，我们还考虑了小胶质细胞如何在某些群体中增加中枢神经系统的易损性，例如老年人和有既往疾病的人。
Coronavirus disease 2019 (COVID-19) is marked by cardio-respiratory alterations, with increasing reports also indicating neurological and psychiatric symptoms in infected individuals. During COVID-19 pathology, the central nervous system (CNS) is possibly affected by direct severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) invasion, exaggerated systemic inflammatory responses, or hypoxia. Psychosocial stress imposed by the pandemic further affects the CNS of COVID-19 patients, but also the non-infected population, potentially contributing to the emergence or exacerbation of various neurological or mental health disorders. Microglia are central players of the CNS homeostasis maintenance and inflammatory response that exert their crucial functions in coordination with other CNS cells. During homeostatic challenges to the brain parenchyma, microglia modify their density, morphology, and molecular signature, resulting in the adjustment of their functions. In this review, we discuss how microglia may be involved in the neuroprotective and neurotoxic responses against CNS insults deriving from COVID-19. We examine how these responses may explain, at least partially, the neurological and psychiatric manifestations reported in COVID-19 patients and the general population. Furthermore, we consider how microglia might contribute to increased CNS vulnerability in certain groups, such as aged individuals and people with pre-existing conditions.
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影响因子：
7.3
作者：
Bhaskar, Sonu;Sinha, Akansha;Kutty, Shelby
通讯作者：
Kutty, Shelby
宿主病毒感染图谱揭示了重症 COVID-19 患者的特征
影响因子：
64.5
作者：
Bost, Pierre;Giladi, Amir;Amit, Ido
通讯作者：
Amit, Ido
影响因子：
9.8
作者：
Abiega O;Beccari S;Diaz-Aparicio I;Nadjar A;Layé S;Leyrolle Q;Gómez-Nicola D;Domercq M;Pérez-Samartín A;Sánchez-Zafra V;Paris I;Valero J;Savage JC;Hui CW;Tremblay MÈ;Deudero JJ;Brewster AL;Anderson AE;Zaldumbide L;Galbarriatu L;Marinas A;Vivanco Md;Matute C;Maletic-Savatic M;Encinas JM;Sierra A
通讯作者：
Sierra A
影响因子：
5.4
作者：
Arbour, N;Côté, G;Talbot, PJ
通讯作者：
Talbot, PJ
影响因子：
6.2
作者：
Bisht K;Sharma KP;Lecours C;Sánchez MG;El Hajj H;Milior G;Olmos-Alonso A;Gómez-Nicola D;Luheshi G;Vallières L;Branchi I;Maggi L;Limatola C;Butovsky O;Tremblay MÈ
通讯作者：
Tremblay MÈ