Host-microbe interactions: commensal fungi in the gut.

Host-microbe interactions: commensal fungi in the gut.
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DOI:
10.1016/j.mib.2017.11.012
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发表时间:
2017-12
影响因子:
5.4
通讯作者:
Underhill DM
Underhill DM
中科院分区:
生物学2区
文献类型:
--
作者:
Paterson MJ;Oh S;Underhill DM

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真菌是普遍存在的微生物,在不同的环境中常见,包括作为人体上的寄生生物。除了其作为消化器官的明显作用外,肠道还被进一步理解为对免疫系统的发育,维持和指导的重要作用。肠道内有许多类型的微生物,包括细菌、古细菌、真菌和病毒,过去几十年的许多研究已经证明了肠道细菌在免疫功能中的重要作用。最近的研究表明,肠道真菌(肠道“真菌生物群”)可能在宿主免疫和炎症中同样发挥重要作用。这篇综述将讨论最近的研究,这将影响我们对肠道真菌在健康和疾病中的作用的理解。
Fungi are ubiquitous microbes that are common in diverse environments including as commensal organisms on the human body. In addition to its obvious role as a digestive organ, the intestines have been further appreciated as important for the development, maintenance, and instruction of the immune system. The gut harbors many types of microorganisms including bacteria, archaea, fungi, and viruses, and many studies over the past couple of decades have documented an important role for intestinal bacteria in immunological function. Recent studies are now suggesting that intestinal fungi (the gut “mycobiome”) may similarly play important roles in host immunity and inflammation. This review will discuss recent studies that will influence our growing understanding of the role(s) of intestinal fungi in health and disease.
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