Aggregated time intensity curves after transarterial chemoembolization with degradable starch microspheres: a feasibility study.
Aggregated time intensity curves after transarterial chemoembolization with degradable starch microspheres: a feasibility study.
复制标题
可降解淀粉微球经动脉化疗栓塞后的聚合时间强度曲线：可行性研究。
DOI：
10.3233/ch-131779
复制
发表时间：
2013
影响因子：
2.1
通讯作者：
P. Wiggermann
中科院分区：
文献类型：
--
作者：
M. Heibl;E. Jung;L. Beyer;Walter A. Wohlgemuth;C. Stroszczynski;P. Wiggermann
目的
应用动态超声造影（DCEUS）和聚集时间-强度曲线（TIC）评价经动脉可降解淀粉微球化疗栓塞（DSM-TACE）后肿瘤灌注情况。
材料和方法
18例患者在DSM-TACE前后通过应用造影剂进行了36次DCEUS检查。基于时间强度曲线（TIC），我们用专用灌注软件分析了栓塞的HCC病灶的微循环。
结果
在所有测量时间点，DSM-TACE后信号强度均显著降低（p ≤ 0.001）。TACE前5、10、15、20和25 s后的平均信号强度分别为375.18 ± 16.41、455.66 ± 17.92、294.47 ± 19.91、246.51 ± 20.99和173.45 ± 25.80，TACE前分别为49.47 ± 2.43、49.51 ± 2.40，TACE后分别为37.40 ± 2.45、27.48 ± 2.65和27.96 ± 3.01。
结论
在这项研究中，可以通过DCEUS和DSM-TACE后聚集的TIC准确评估肿瘤灌注。
PURPOSE
To evaluate tumor perfusion by means of dynamic contrast-enhanced ultrasonography (DCEUS) and aggregated time intensity curves (TICs) after transarterial chemoembolization with degradable starch microspheres (DSM-TACE).
MATERIAL AND METHODS
18 patients underwent 36 DCEUS examinations conducted via contrast agent application before and after DSM-TACE. Based on time intensity curves (TICs), we analyzed the microcirculation of the embolized HCC lesions with a dedicated perfusion software.
RESULTS
Signal intensity was significantly reduced (p ≤ 0.001) after DSM-TACE at all time points measured. The mean signal intensity after 5, 10, 15, 20 and 25 s was 375.18 ± 16.41, 455.66 ± 17.92, 294.47 ± 19.91, 246.51 ± 20.99 and 173.45 ± 25.80 before TACE and 49.47 ± 2.43, 49.51 ± 2.40, 37.40 ± 2.45, 27.48 ± 2.65 and 27.96 ± 3.01 after TACE.
CONCLUSION
In this study, tumor perfusion could be accurately evaluated by means of DCEUS and aggregated TICs after DSM-TACE.