Paroxysmal attacks in multiple sclerosis
Paroxysmal attacks in multiple sclerosis
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DOI：
10.1177/135245850100700609
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发表时间：
2001-12-01
期刊：
影响因子：
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通讯作者：
Eraksoy, M
中科院分区：
文献类型：
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作者：
Tüzün, E;Akman-Demir, G;Eraksoy, M
多发性硬化（MS）患者的阵发性发作是一种短暂、频繁和刻板的症状。我们回顾性地评估了患者的临床和神经放射学结果，这些患者在疾病过程中发生了任何阵发性发作。将59例阵发性发作患者（组I）的EDSS评分、MS临床类型和疾病持续时间与我们MS数据库中记录的586例连续无阵发性发作患者（组2）进行比较。在阵发性发作6个月内进行MRI检查的31例患者中，尝试了解剖学和临床相关性。第1组患者发作时的EDSS评分显著低于其失去门诊访视时的评分，而其他参数无显著差异。我们的研究结果表明，阵发性发作发生在病程的早期，此时很少或没有神经功能障碍和相关的组织损伤。
Paroxysmal attacks ore short, frequent and stereotyped symptoms that can be observed in multiple sclerosis (MS) patients. We evaluated retrospectively the clinical and neuroradiological findings of patients, who developed any paroxysmal attacks during the course of their disease. EDSS scores, MS clinical types and disease durations of 59 patients with paroxysmal attacks (Group I) were compared to 586 consecutive patients without paroxysmal attacks recorded in our MS database (Group 2). Anatomical and clinical correlation was attempted in 31 of the patients who had MRI examinations performed within 6 months of the paroxysmal attacks. EDSS scores of patients in Group 1 at the time of the paroxysmal attacks were significantly lower than the scores at their lost clinic visit, whereas there were no significant differences for other parameters. Our results demonstrate that paroxysmal attacks occur early in the course of the disease, when there is little or no neurologic disability and associated tissue damage.