Serum Levels of Toxic AGEs (TAGE) May Be a Promising Novel Biomarker for the Onset/Progression of Lifestyle-Related Diseases.
Serum Levels of Toxic AGEs (TAGE) May Be a Promising Novel Biomarker for the Onset/Progression of Lifestyle-Related Diseases.
复制标题
血清毒性时代水平（Tage）可能是与生活方式相关疾病的发作/进展的有前途的新型生物标志物。
DOI：
10.3390/diagnostics6020023
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发表时间：
2016-06-07
期刊：
影响因子：
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通讯作者：
Takeuchi M
中科院分区：
文献类型：
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作者：
Takeuchi M
衰老或糖尿病存在时产生的晚期糖基化终产物（AGE），特别是源自葡萄糖/果糖代谢中间体甘油醛的AGE（甘油-AGE；称为毒性AGE（TAGE）），最近被证明通过AGE受体（RAGE）与糖尿病血管并发症的发生/进展密切相关。 TAGE 还会导致多种疾病，例如心血管疾病；非酒精性脂肪性肝炎；癌症;阿尔茨海默病；不孕症。这表明有必要最大限度地减少 TAGE-RAGE 轴的影响，以预防生活方式相关疾病 (LSRD) 的发作/进展并制定治疗策略。血清 TAGE 水平的变化与 LSRD 密切相关，LSRD 与暴饮暴食、缺乏运动或过量摄入糖/膳食 AGE 相关。我们还表明，血清 TAGE 水平（而非血红蛋白 A1c、葡萄糖衍生的 AGE 或 Nε-（羧甲基）赖氨酸）有潜力作为预测动脉粥样硬化进展和未来心血管事件的生物标志物。我们在此介绍血清TAGE水平作为生物标志物在预防/早期诊断LSRD和评估治疗效果方面的用途；我们讨论饮食中 AGE/糖摄入限制是否会减少 TAGE 的产生/积累，从而预防 LSRD 的发生/进展。
Advanced glycation end-products (AGEs) generated with aging or in the presence of diabetes mellitus, particularly AGEs derived from the glucose/fructose metabolism intermediate glyceraldehyde (Glycer-AGEs; termed toxic AGEs (TAGE)), were recently shown to be closely involved in the onset/progression of diabetic vascular complications via the receptor for AGEs (RAGE). TAGE also contribute to various diseases, such as cardiovascular disease; nonalcoholic steatohepatitis; cancer; Alzheimer’s disease, and; infertility. This suggests the necessity of minimizing the influence of the TAGE-RAGE axis in order to prevent the onset/progression of lifestyle-related diseases (LSRD) and establish therapeutic strategies. Changes in serum TAGE levels are closely associated with LSRD related to overeating, a lack of exercise, or excessive ingestion of sugars/dietary AGEs. We also showed that serum TAGE levels, but not those of hemoglobin A1c, glucose-derived AGEs, or Nε-(carboxymethyl)lysine, have potential as a biomarker for predicting the progression of atherosclerosis and future cardiovascular events. We herein introduce the usefulness of serum TAGE levels as a biomarker for the prevention/early diagnosis of LSRD and the evaluation of the efficacy of treatments; we discuss whether dietary AGE/sugar intake restrictions reduce the generation/accumulation of TAGE, thereby preventing the onset/progression of LSRD.