[Study on risk factors of lung cancer in non-smoking women].
[Study on risk factors of lung cancer in non-smoking women].
复制标题
DOI：
10.3779/j.issn.1009-3419.2005.04.06
复制
发表时间：
2005-08-20
期刊：
影响因子：
--
通讯作者：
Zhou, Baosen
中科院分区：
文献类型：
--
作者：
Shi, Hailong;He, Qincheng;Zhou, Baosen
背景：肺癌是一个严重的公共健康问题。其发病率和死亡率一直在迅速上升。女性肺癌死亡率也呈逐年上升趋势，其中病例多为非吸烟女性，其危险因素尚不清楚。本研究旨在探讨室内空气污染、被动吸烟等因素对肺癌发病风险的影响。对照组在市区普通人群中随机抽取。两名训练有素的面试者使用相同的问卷进行了面对面的面试。问卷内容包括人口学特征、被动吸烟史、烹调油烟暴露史、燃料暴露史、煤烟暴露史、使用“康乐”史、肺部疾病史、亲属癌症史和职业史。结果：儿童时期被动吸烟与非吸烟女性肺癌的发生有关(OR=1.81，95%CI=1.46~2.24)。接触油烟有显著意义(OR=3.18，95%CI=2.55~3.97)。煤烟与肺癌的关系显著(OR=2.56，95%CI=1.83~4.55)。肺结核、慢性支气管炎、哮喘、肺炎、肺气肿等肺部疾病史与肺癌密切相关(OR=1.80，95%CI=1.43~2.27)。癌症家族史显著增加患肺癌的危险性(OR=2.09，95%CI=1.46~3.00)，尤其是第一亲属的肺癌史(OR=2.46，95%CI=1.55~3.90)。在调整其他因素后，Logistic回归分析显示，烹饪油烟(OR=4.11，95%CI=2.14~7.89)、肺部疾病史(OR=2.05，95%CI=1.08~3.93)、肺癌家族史(OR=2.89，95%CI=1.30~6.41)是非吸烟女性肺癌的危险因素。
BACKGROUND: Lung cancer is a serious health problem in public. Its morbidity and mortality have been increasing rapidly. The mortality of lung cancer in women also increases year by year, in which most of the cases are non-smoking women, and the risk factors still are unclear. The aim of this study is to explore the effects of air pollution in room, passive smoking and other factors on risk of lung cancer.METHODS: A total of 618 newly diagnosed female patients with primary lung cancer were enrolled. The controls were selected randomly in the general population in urban districts. Two trained interviewers performed this interview face-to-face using the same questionnaire. The content of questionnaire included the characteristics of demography, history of passive smoking, exposed history of cooking fume, fuel exposure, exposed history of coal fume, history of using 'Kang', pulmonary disease history, cancer history of relatives and occupational history.RESULTS: Passive smoking in childhood was related with lung cancer of non-smoking women (OR= 1.81 , 95%CI=1.46-2.24). The exposure to the cooking fume was of great significance (OR=3.18, 95%CI= 2.55 -3.97). The relationship between coal fume and lung cancer was significant (OR=2.56, 95%CI= 1.83 -4.55). The pulmonary disease history including tuberculosis, chronic bronchitis, asthma, pneumonia, emphysema was strongly associated with lung cancer (OR=1.80, 95%CI=1.43-2.27). The family history of cancer significantly increased the risk of lung cancer (OR=2.09, 95%CI=1.46-3.00), especially the lung cancer history in the first relatives (OR=2.46, 95%CI=1.55-3.90). After adjusting other factors, logistic analysis showed that cooking fume (OR=4.11, 95%CI=2.14-7.89), the pulmonary disease history (OR= 2.05 , 95%CI=1.08-3.93), and the family history of lung cancer (OR=2.89, 95%CI=1.30-6.41) were significant factors.CONCLUSIONS: The results show that passive smoking in childhood, cooking oil exposure, coal fume exposure, pulmonary disease history including tuberculosis and family history of lung cancer are risk factors of lung cancer in non-smoking women.