Resting-state brain networks revealed by granger causal connectivity in frogs
Resting-state brain networks revealed by granger causal connectivity in frogs
复制标题
格兰杰因果连接揭示青蛙静息态大脑网络
DOI：
10.1016/j.neuroscience.2016.08.015
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发表时间：
2016
期刊：
影响因子：
3.3
通讯作者：
Tang Yezhong
中科院分区：
文献类型：
--
作者：
Xue Fei;Fang Guangzhan;Yue Xizi;Zhao Ermi;Brauth Steven E.;Tang Yezhong
静息态网络（RSNs）是指在静息状态下产生的自发脑活动，它维持着脑功能网络的动态连接，以实现自动感知或更高级的认知功能。本文采用格兰杰因果连接分析（GCCA）方法，对不同行为活动阶段的音乐蛙脑RSN进行了研究。结果表明，青蛙大脑中的因果网络可以在休息状态下，这反映了大脑侧化和性别二态性。具体来说：（1）从左侧中脑到端脑两侧的上行因果联系显著高于右侧中脑，而右侧端脑在所有脑区中产生最强的传出投射;（2）女性左侧中脑的因果联系显著高于男性;（3）这些连接在该物种的高和低行为活动阶段期间是相似的，尽管对于所有节点，几乎所有脑电图（EEG）谱带在高活动阶段显示出更高的功率。该网络的功能特征与该物种听觉感知的重要特征相匹配。因此，我们建议，这种因果网络保持听觉感知在休息状态下的意外听觉输入的休息状态网络在其他物种。这些结果也与雌性在生殖季节对听觉刺激比雄性更敏感的观点一致。此外，这些结果意味着，即使没有行为活跃，青蛙仍然保持警惕，以检测外部刺激。
Resting-state networks (RSNs) refer to the spontaneous brain activity generated under resting conditions, which maintain the dynamic connectivity of functional brain networks for automatic perception or higher order cognitive functions. Here, Granger causal connectivity analysis (GCCA) was used to explore brain RSNs in the music frog (Babina daunchina) during different behavioral activity phases. The results reveal that a causal network in the frog brain can be identified during the resting state which reflects both brain lateralization and sexual dimorphism. Specifically (1) ascending causal connections from the left mesencephalon to both sides of the telencephalon are significantly higher than those from the right mesencephalon, while the right telencephalon gives rise to the strongest efferent projections among all brain regions; (2) causal connections from the left mesencephalon in females are significantly higher than those in males and (3) these connections are similar during both the high and low behavioral activity phases in this species although almost all electroencephalograph (EEG) spectral bands showed higher power in the high activity phase for all nodes. The functional features of this network match important characteristics of auditory perception in this species. Thus we propose that this causal network maintains auditory perception during the resting state for unexpected auditory inputs as resting-state networks do in other species. These results are also consistent with the idea that females are more sensitive to auditory stimuli than males during the reproductive season. In addition, these results imply that even when not behaviorally active, the frogs remain vigilant for detecting external stimuli.