Recognition and Activation by Ureas and Thioureas: Stereoselective Reactions Using Ureas and Thioureas as Hydrogen-Bonding Donors
Recognition and Activation by Ureas and Thioureas: Stereoselective Reactions Using Ureas and Thioureas as Hydrogen-Bonding Donors
复制标题
DOI：
10.1002/chin.200615239
复制
发表时间：
2006-04
期刊：
影响因子：
--
通讯作者：
Y. Takemoto
中科院分区：
文献类型：
--
作者：
Y. Takemoto
氢键相互作用在生物体中由酶和抗体介导的各种生物重要反应的分子识别和活化过程中起着至关重要的作用。最近，已经表明氢键供体可以用作有机化学中各种类型反应的通用酸催化剂。本文综述了脲和硫脲衍生物作为一般酸催化剂催化的对映选择性反应以及非对映选择性反应。本文概述了这一快速发展的领域。
Hydrogen-bonding interaction plays a crucial role in the molecular recognition and activation processes of various biologically important reactions that are mediated by enzymes and antibodies in living organisms. Recently, it has been shown that a hydrogen-bonding donor can be used as a general acid catalyst for various types of reactions in organic chemistry. In this article, we describe enantioselective reactions catalyzed by urea and thiourea derivatives as general acid catalysts as well as diastereoselective reactions. This perspective provides an overview of this rapidly growing field.