Genomic analysis reveals hidden biodiversity within colugos, the sister group to primates.
Genomic analysis reveals hidden biodiversity within colugos, the sister group to primates.
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DOI：
10.1126/sciadv.1600633
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发表时间：
2016-08
期刊：
影响因子：
13.6
通讯作者：
Murphy WJ
中科院分区：
文献类型：
--
作者：
Mason VC;Li G;Minx P;Schmitz J;Churakov G;Doronina L;Melin AD;Dominy NJ;Lim NT;Springer MS;Wilson RK;Warren WC;Helgen KM;Murphy WJ
猫猴基因组揭示了隐藏的生物多样性和灵长类动物的姐妹群。猫猴是研究最少的哺乳动物之一，尽管它们在解决灵长类的超序关系方面发挥着中心作用。这些滑翔哺乳动物的两个描述的物种是唯一的生活成员Dermoptera，分布在整个东南亚。我们生成了巽他猫猴和菲律宾猫猴参考比对的基因组序列草案，并使用这些来识别猫猴特异性的遗传变化，这些遗传变化富含感觉和肌肉相关基因，这些基因可能是它们夜间和滑翔适应的基础。系统基因组分析和罕见的基因组变化目录压倒性地支持了有争议的假设，即猫猴是灵长类动物（灵长目）的姐妹群，而不包括树鼩。我们从猫猴博物馆标本中采集了约140 kb的正向序列数据，并在许多地理隔离的种群之间发现了巨大的遗传差异，这可能导致已识别的猫猴物种数量增加300%。我们的研究结果确定保护单位，以减轻未来的损失，这个神秘的哺乳动物秩序。
The colugo genome reveals hidden biodiversity and the sister group to primates. Colugos are among the most poorly studied mammals despite their centrality to resolving supraordinal primate relationships. Two described species of these gliding mammals are the sole living members of the order Dermoptera, distributed throughout Southeast Asia. We generated a draft genome sequence for a Sunda colugo and a Philippine colugo reference alignment, and used these to identify colugo-specific genetic changes that were enriched in sensory and musculoskeletal-related genes that likely underlie their nocturnal and gliding adaptations. Phylogenomic analysis and catalogs of rare genomic changes overwhelmingly support the contested hypothesis that colugos are the sister group to primates (Primatomorpha), to the exclusion of treeshrews. We captured ~140 kb of orthologous sequence data from colugo museum specimens sampled across their range and identified large genetic differences between many geographically isolated populations that may result in a >300% increase in the number of recognized colugo species. Our results identify conservation units to mitigate future losses of this enigmatic mammalian order.