The potential role of apoptosis in human disease
The potential role of apoptosis in human disease
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DOI：
10.1159/000054240
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发表时间：
2000-05-01
影响因子：
3.2
通讯作者：
Zhivotovsky, B
中科院分区：
文献类型：
--
作者：
Fadeel, B;Orrenius, S;Zhivotovsky, B
细胞程序性死亡或凋亡是一个进化上保守的过程，对于维持组织内稳态至关重要。最近的研究表明细胞凋亡在多种人类疾病中的作用。因此，细胞凋亡的失调与例如全身性和器官特异性自身免疫性疾病、获得性免疫缺陷综合征、神经退行性疾病、动脉粥样硬化和癌症有关。本报告作为一个概述的病理条件，这是与缺陷或意外的细胞凋亡，与疾病的例子，其中假定的细胞凋亡缺陷已阐明在分子水平上。还提供了细胞凋亡作为治疗干预靶点的关键评估。版权所有（C）2001 S. Karger AG，巴塞尔。
Programmed cell death or apoptosis is an evolutionarily conserved process which is essential for the maintenance of tissue homeostasis. Recent studies have indicated a role for apoptosis in a variety of human diseases. Hence, dysregulation of apoptosis has been implicated in, for instance, systemic and organ-specific autoimmune disease, acquired immune deficiency syndrome, neurodegenerative disorders, atherosclerosis and cancer. This presentation serves as an overview of pathological conditions, which are associated with defective or inadvertent apoptosis, with examples of disorders in which putative apoptosis defects have been elucidated at the molecular level. A critical assessment of apoptosis as a target for therapeutic intervention is also provided. Copyright (C) 2001 S. Karger AG, Basel.