Correlation Analysis of Quantitative Diffusion Parameters in Ipsilateral Cerebral Peduncle during Wallerian Degeneration with Motor Function Outcome after Cerebral Ischemic Stroke
Correlation Analysis of Quantitative Diffusion Parameters in Ipsilateral Cerebral Peduncle during Wallerian Degeneration with Motor Function Outcome after Cerebral Ischemic Stroke
复制标题
DOI：
10.1111/j.1552-6569.2011.00617.x
复制
发表时间：
2012-07-01
影响因子：
2.4
通讯作者：
Wang, Henry Z.
中科院分区：
文献类型：
--
作者：
Liu, Xiang;Tian, Wei;Wang, Henry Z.
背景与目的探讨沃勒变性（Wallerian degeneration，WD）发生的时间段，以及应用同侧皮质脊髓束（corticalspinal tract，CST）弥散参数预测脑梗死后运动功能预后的价值。方法回顾性研究48例沿着CST行弥散张量成像的WD患者，根据发病后的时间点分为4组，第1组：发病后2周内;第2组：发病后3 ~ 4周;第3组：发病后5 ~ 14周;第4组：发病后14周。计算大脑脚的表观弥散系数（ADC）、各向异性分数（FA）及其比值（=同侧弥散值/对侧弥散值）。评估各组影像学参数与卒中后8个月运动功能评分的相关性。结果第1组FA比率（rFA）与运动功能评分无明显相关性（P= .05）。在其他组中，rFA和FA与运动功能评分相关（每组P <0.001）。ADC比值和同侧ADC值仅在第4组中与运动功能评分显著相关（分别为P= 0.016和0.029）。结论：卒中发作2周后的rFA和同侧FA值与运动功能结局相关。
BACKGROUND AND PURPOSE To evaluate the time periods of Wallerian degeneration (WD) in which the diffusion parameters of ipsilateral corticalspinal tract (CST) can be used to predict the motor function outcome after brain infarction. METHODS This retrospective study classified 48 diffusion tensor imaging patients with WD along CST into four groups based on the following time points after stroke onset, Group 1: within the first 2 weeks; Group 2: from 3 to 4 weeks; Group 3: from 5 to 14 weeks; Group 4: after 14 weeks. The apparent diffusion coefficient (ADC), fractional anisotropy (FA), and their ratios (=ipsilateral diffusion value/contralateral value) of cerebral peduncle were evaluated. The correlation between imaging parameters in each group and the motor function scores appraised at 8 months after stroke onset were assessed. RESULTS There was no evident correlation of FA ratio (rFA) in Group 1 with motor function score (P= .05). The rFA and FA correlated with motor function score in other groups (P < .001 in each group). The ADC ratio and ipsilateral ADC value only showed significant correlation of with motor function score in Group 4 (P= .016 and .029, respectively). CONCLUSIONS The rFA and ipsilateral FA values after 2 weeks of stroke onset correlate with the motor function outcome.