Optical focusing inside scattering media with time-reversed ultrasound microbubble encoded light.
Optical focusing inside scattering media with time-reversed ultrasound microbubble encoded light.
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DOI：
10.1038/ncomms9968
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发表时间：
2015-11-24
影响因子：
16.6
通讯作者：
Yang C
中科院分区：
文献类型：
--
作者：
Ruan H;Jang M;Yang C
Focusing light inside scattering media in a freely addressable fashion is challenging, as the wavefront of the scattered light is highly disordered. Recently developed ultrasound-guided wavefront shaping methods are addressing this challenge, albeit with relatively low modulation efficiency and resolution limitations. In this paper, we present a new technique, time-reversed ultrasound microbubble encoded (TRUME) optical focusing, which can focus light with improved efficiency and sub-ultrasound wavelength resolution. This method ultrasonically destroys microbubbles, and measures the wavefront change to compute and render a suitable time-reversed wavefront solution for focusing. We demonstrate that the TRUME technique can create an optical focus at the site of bubble destruction with a size of ∼2 μm. We further demonstrate a twofold enhancement in addressable focus resolution in a microbubble aggregate target by exploiting the nonlinear pressure-to-destruction response of the microbubbles. The reported technique provides a deep tissue-focusing solution with high efficiency, resolution, and specificity. Focusing light inside biological tissue is challenging due to its strong scattering nature. Here, the authors develop a technique that uses ultrasonically destroyed microbubbles to assist in the computation of a wavefront solution which forms optical foci at the microbubble destruction sites.
