GABA levels and measures of intracortical and interhemispheric excitability in healthy young and older adults: an MRS-TMS study
GABA levels and measures of intracortical and interhemispheric excitability in healthy young and older adults: an MRS-TMS study
复制标题
健康青年和老年人大脑皮层内和大脑半球间兴奋性的GABA水平和测量：一项MRS-TMS研究
DOI：
10.1016/j.neurobiolaging.2018.01.023
复制
发表时间：
2018-05-01
影响因子：
4.2
通讯作者：
Cuypers, Koen
中科院分区：
文献类型：
--
作者：
Hermans, Lize;Levin, Oron;Cuypers, Koen
编辑磁共振波谱（MRS）和经颅磁刺激（TMS）经常被用来研究健康老年人GABA能神经传递系统的完整性。为了研究在老年人中使用这两种技术获得的测量结果是否相互关联，在28名老年人（63-74岁）和28名年轻人（19-34岁）中使用编辑的MRS评估了左侧感觉运动皮层中的γ-氨基丁酸（GABA）水平。然后使用静息TMS测量皮质内抑制（短间隔皮质内抑制/长间隔皮质内抑制）、皮质内易化、从左侧到右侧初级运动皮质（M1）的半球间抑制以及左侧和右侧M1的募集曲线。我们的观察结果表明，短时间间隔内皮层抑制和长时间间隔内皮层抑制在左侧M1减少老年人，而GABA水平没有显着不同的年龄组。此外，MRS评估的GABA在左侧感觉运动皮层与TMS评估的皮层兴奋性或抑制性不相关。这些观察结果表明，健康老龄化引起突触后受体水平的抑制改变，这似乎与MRS评估的GABA+水平无关。(C)2018爱思唯尔公司All rights reserved.
Edited magnetic resonance spectroscopy (MRS) and transcranial magnetic stimulation (TMS) have often been used to study the integrity of the GABAergic neurotransmission system in healthy aging. To investigate whether the measurement outcomes obtained with these 2 techniques are associated with each other in older human adults, gamma-aminobutyric acid (GABA) levels in the left sensorimotor cortex were assessed with edited MRS in 28 older (63-74 years) and 28 young adults (19-34 years). TMS at rest was then used to measure intracortical inhibition (short-interval intracortical inhibition/long-interval intracortical inhibition), intracortical facilitation, interhemispheric inhibition from left to right primary motor cortex (M1) and recruitment curves of left and right M1. Our observations showed that short-interval intracortical inhibition and long-interval intracortical inhibition in the left M1 were reduced in older adults, while GABA levels did not significantly differ between age groups. Furthermore, MRS-assessed GABA within left sensorimotor cortex was not correlated with TMS-assessed cortical excitability or inhibition. These observations suggest that healthy aging gives rise to altered inhibition at the postsynaptic receptor level, which does not seem to be associated with MRS-assessed GABA+ levels. (C) 2018 Elsevier Inc. All rights reserved.