Role of neuroinflammation in neurodegenerative diseases (Review).
Role of neuroinflammation in neurodegenerative diseases (Review).
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DOI：
10.3892/mmr.2016.4948
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发表时间：
2016-04
影响因子：
3.4
通讯作者：
Huang WJ
中科院分区：
文献类型：
--
作者：
Chen WW;Zhang X;Huang WJ
神经变性是一种发生在中枢神经系统的现象，通过与神经元结构和功能丧失相关的标志。神经变性是在病毒侵袭后观察到的，主要是在各种所谓的“神经退行性疾病”中观察到的，通常在老年人中观察到，如阿尔茨海默病、多发性硬化症、帕金森病和肌萎缩侧索硬化症，这些疾病对精神和身体功能产生负面影响。神经退行性疾病的致病因子尚未确定。然而，最近的数据已经确定炎症过程与多种神经退行性通路密切相关，这些通路与抑郁症（神经退行性疾病的后果）有关。因此，促炎细胞因子在抑郁症和痴呆的病理生理中很重要。这些数据表明，神经炎症在神经退行性变中的作用必须充分阐明，因为促炎剂是神经炎症的致病作用，广泛存在，特别是在老年人中，炎症机制与功能和精神损伤的发病机制有关。在这篇综述中，我们研究了炎症过程在神经退行性疾病中的作用。
Neurodegeneration is a phenomenon that occurs in the central nervous system through the hallmarks associating the loss of neuronal structure and function. Neurodegeneration is observed after viral insult and mostly in various so-called 'neurodegenerative diseases', generally observed in the elderly, such as Alzheimer's disease, multiple sclerosis, Parkinson's disease and amyotrophic lateral sclerosis that negatively affect mental and physical functioning. Causative agents of neurodegeneration have yet to be identified. However, recent data have identified the inflammatory process as being closely linked with multiple neurodegenerative pathways, which are associated with depression, a consequence of neurodegenerative disease. Accordingly, pro-inflammatory cytokines are important in the pathophysiology of depression and dementia. These data suggest that the role of neuroinflammation in neurodegeneration must be fully elucidated, since pro-inflammatory agents, which are the causative effects of neuroinflammation, occur widely, particularly in the elderly in whom inflammatory mechanisms are linked to the pathogenesis of functional and mental impairments. In this review, we investigated the role played by the inflammatory process in neurodegenerative diseases.