Bipolar disorder and polymorphisms of glutathione S-transferases M1 (GSTM1) and T1 (GSTT1)
Bipolar disorder and polymorphisms of glutathione S-transferases M1 (GSTM1) and T1 (GSTT1)
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DOI：
10.1016/j.psychres.2010.06.017
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发表时间：
2011-03-30
影响因子：
11.3
通讯作者：
Saadat, Mostafa
中科院分区：
文献类型：
--
作者：
Mohammadynejad, Parisa;Saadat, Iraj;Saadat, Mostafa
谷胱甘肽S-转移酶是一种普遍存在的多功能酶，在细胞解毒过程中起着关键作用。本病例对照研究是在伊朗设拉子进行的，旨在调查谷胱甘肽S-转移酶M1（GSTM 1）和T1（GSTT 1）多态性与双相情感障碍（BPD）易感性之间的关系。共有228名BPD患者参加了这项研究。此外，还将236名与患者年龄和性别匹配的健康献血者作为对照组进行了研究。统计学分析显示，GSTM 1（OR = 0.73，95%CI：0.50-1.05）和GSTT 1（OR = 0.98，95%CI：0.65-1.47）基因多态性与BPD的发病风险无关。根据发病年龄将患者分为早发性（19岁以下）和晚发性（19岁以上）组。在早发组中，GSTM 1缺失基因型降低BPD的发病风险（OR = 0.43，95% CI：0.24-0.79）。进一步分析表明，“GSTM 1阳性基因型+GSTT 1缺失基因型”与“GSTM 1 + GSTT 1阳性基因型”相结合可增加BPD的发病风险（OR = 2.28，95% CI：1.07-4.85）。然而，在晚发型组中，研究多态性与BPD风险之间没有显著相关性。本研究结果表明，GSTM 1和GSTT 1是候选多态性的易感性BDP青少年。(C)2010爱思唯尔爱尔兰有限公司版权所有。
Glutathione S-transferases are ubiquitous multifunctional enzymes, which play a key role in cellular detoxification. The present case-control study was performed in Shiraz, Iran to investigate the association between polymorphisms of glutathione S-transferases M1 (GSTM1) and T1 (GSTT1) and susceptibility to bipolar disorder (BPD). A total of 228 BPD patients participated in the study. In addition, 236 healthy blood donors, who frequency matched with the patients according to age and gender, were also studied as a control group. Statistical analysis revealed that polymorphisms of neither GSTM1 (OR = 0.73, 95% CI: 0.50-1.05) nor GSTT1 (OR = 0.98, 95% Cl: 0.65-1.47) were associated with risk of BPD. Patients were stratified according to their age of onset into early onset (below 19 years old) and late onset (more than 19 years old) groups. Among the early onset group, the GSTM1 null genotype decreases the risk of BPD (OR = 0.43, 95% Cl: 0.24-0.79). Further analysis showed that a combination of "GSTM1 positive genotype and GSTT1 null genotype" versus "positive genotypes of GSTM1 and GSTT1" increased the risk of BPD (OR = 2.28, 95% Cl: 1.07-4.85). However, there was no significant association between the study polymorphisms and risk of BPD among the late onset group. The present finding indicated that GSTM1 and GSTT1 are candidate polymorphisms for susceptibility to BDP among adolescents. (C) 2010 Elsevier Ireland Ltd. All rights reserved.