Gonococcal adherence: selected topics.
Gonococcal adherence: selected topics.
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淋球菌依从性：选定的主题。
DOI：
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发表时间：
1983
期刊：
影响因子：
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通讯作者：
J. Swanson
中科院分区：
文献类型：
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作者：
J. Swanson
淋球菌粘附于人类宿主上皮表面似乎是淋病发病机制中的一个重要特征。获得和保持密切的协会与上皮细胞可能涉及淋球菌上皮细胞和淋球菌淋球菌的相互作用，这表明，两个不同的淋球菌表面成分-皮利和外膜蛋白II-发挥互补作用，促进这些密切的协会与粘膜细胞。皮利和外膜蛋白II都以几种不同的分子形式存在于给定菌株的淋球菌中，并且每种特定形式的表达在体外以高频率变化。如果在体内发生类似的变化，淋球菌可能有一个相当大的表面外观库，以科普宿主的变化或不同的细胞和体液成分。
Gonococcal adherence to human host epithelial surfaces appears to be an important feature in pathogenesis of gonorrhea. Attaining and maintaining close association with epithelial cells may involve interactions of both gonococcus to epithelial cell and gonococcus to gonococcus; it is suggested that two distinct gonococcal surface components--pili and outer membrane protein II--play complementary roles in promoting these close associations with mucosal cells. Both pili and outer membrane protein II occur in several different molecular forms among gonococci of a given strain, and expression of a particular form of each changes at high frequency in vitro. If analogous changes occur in vivo, gonococci may have a sizeable repertoire of surface facades to cope with changing or different cellular and humoral components of the host.