Malaria protection in β2‐microglobulin‐deficient mice lacking major histocompatibility complex class I antigens: essential role of innate immunity, including γδT cells
Malaria protection in β2‐microglobulin‐deficient mice lacking major histocompatibility complex class I antigens: essential role of innate immunity, including γδT cells
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DOI：
10.1111/j.1365-2567.2007.02661.x
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发表时间：
2007-12
期刊：
影响因子：
6.4
通讯作者：
T. Taniguchi;S. Tachikawa;Yasuhiro Kanda;T. Kawamura;C. Tomiyama-Miyaji;Changchun Li;Hisami Watanabe;H. Sekikawa;T. Abo
中科院分区：
文献类型：
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作者：
T. Taniguchi;S. Tachikawa;Yasuhiro Kanda;T. Kawamura;C. Tomiyama-Miyaji;Changchun Li;Hisami Watanabe;H. Sekikawa;T. Abo
疟疾保护作用是由与T和B细胞相关的常规免疫介导，还是由与胸腺外T细胞和产生自身抗体的B细胞相关的先天免疫介导，目前仍有争议。鉴于这种情况，重要的是要检查β2微球蛋白缺陷（β 2 m（-/-））小鼠中的疟疾保护机制。这些小鼠缺乏主要组织相容性复合物I类和CD 1d抗原，这导致缺乏CD 8 + T细胞和自然杀伤T（NKT）细胞。当C57 BL/6和β 2 m（-/-）小鼠注射寄生虫（约氏疟原虫17 XNL）红细胞时，两者均从感染中存活，并显示出相似的寄生虫血症水平。在两只小鼠中，主要扩增的T细胞是NK 1.1- αβ T-细胞受体细胞。不同之处在于β 2 m（-/-）小鼠中NK和γδT细胞的代偿性扩增，消除实验表明这些淋巴细胞对这些小鼠的保护至关重要。这些结果表明，疟疾保护可能是与具有自身反应性的多个亚群相关的先天免疫事件。CD 8 + T细胞和NKT细胞可能与这种保护作用部分相关。
It is still controversial whether malaria protection is mediated by conventional immunity associated with T and B cells or by innate immunity associated with extrathymic T cells and autoantibody‐producing B cells. Given this situation, it is important to examine the mechanism of malaria protection in β2‐microglobulin‐deficient (β2m(–/–)) mice. These mice lack major histocompatibility complex class I and CD1d antigens, which results in the absence of CD8+ T cells and natural killer T (NKT) cells. When C57BL/6 and β2m(–/–) mice were injected with parasitized (Plasmodium yoelii 17XNL) erythrocytes, both survived from the infection and showed a similar level of parasitaemia. The major expanding T cells were NK1.1– αβΤ‐cell receptorint cells in both mice. The difference was a compensatory expansion of NK and γδT cells in β2m(–/–) mice, and an elimination experiment showed that these lymphocytes were critical for protection in these mice. These results suggest that malaria protection might be events of the innate immunity associated with multiple subsets with autoreactivity. CD8+ T and NKT cells may be partially related to this protection.