Disposition of 9-aminoacridine in rats dosed orally or intravenously and in monkeys dosed topically.
Disposition of 9-aminoacridine in rats dosed orally or intravenously and in monkeys dosed topically.
复制标题
9-氨基吖啶在口服或静脉给药的大鼠和局部给药的猴子中的处置。
DOI：
10.1080/15287398509530705
复制
发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Hill,DL
中科院分区：
文献类型：
--
作者：
elDareer,SM;Kalin,JR;Tillery,KF;Hill,DL
Following administration of [14C]‐labeled 9‐aminoacridine ([14C] 9AA) hydrochloride either orally or intravenously to rats, the excretion of radioactivity was similar, with 20–26% of the dose appearing in the urine and 57–68% in the feces. The pattern of tissue distribution was also similar for the two routes. This information suggests that absorption of the oral doses was extensive and that, for both routes of administration, biliary excretion accounted for most of the radioactivity in the feces. Biliary excretion of radioactivity derived from [14C] 9AA was confirmed in an experiment involving rats with inserted biliary cannulas. For these rats, 49.5% of the dose administered appeared in the bile in 4 h. The major urinary and biliary metabolite of [14C] 9AA of rats was identified as an O‐β‐glucuronide of hydroxylated 9AA.Absorption of 9AA through the skin could not be conclusively demonstrated. For monkeys dosed topically with [14C]9AA, only small amounts of radioactivity (a total of < 0.8% of the dose) appeared in the urine and various tissues in 24 h.
