EFFECT OF MONOCROTALINE INGESTION ON LIVER, KIDNEY, AND LUNG OF RATS
EFFECT OF MONOCROTALINE INGESTION ON LIVER, KIDNEY, AND LUNG OF RATS
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DOI：
10.1016/0041-008x(91)90223-2
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发表时间：
1981-01-01
影响因子：
3.8
通讯作者：
HOOK, JB
中科院分区：
文献类型：
--
作者：
ROTH, RA;DOTZLAF, LA;HOOK, JB
对年轻雄性大鼠在饮用水中随意给予野百合碱（MCT）（22 μ g/ml）长达28天，并检查肺、肝和肾中的毒性发展。灌流的5-羟色胺的清除率由处理大鼠的离体肺早在14天下降。这伴随着肺/体重比和无细胞支气管肺泡灌洗液中乳酸脱氢酶活性的增加。MCT给药21天后，右心肥大和离体肺流入灌注压升高明显。所有参数的变化幅度随治疗持续时间增加。治疗28天后，胆汁吲哚菁绿色排泄减少，血浆谷氨酰胺转氨酶活性略有升高。给药（28天）还导致血尿素氮升高，肾片对氨基马尿酸蓄积减少，肾片四乙铵蓄积增加。肺、肝脏和肾脏均受到该MCT给药方案的影响，对肺的功能影响先于对其他组织的影响。
Young male rats were administered monocrotaline (MCT) ad lib in the drinking water (22 .mu.g/ml) for up to 28 days, and the development of toxicity in lung, liver and kidney was examined. Clearance of perfused 5-hydroxytryptamine by isolated lungs of treated rats was decreased as early as 14 days. This was accompanied by increases in lung/body weight ratio and in lactate dehydrogenase activity in cell-free bronchopulmonary lavage fluid. Hypertrophy of the right heart and increased inflow perfusion pressure of isolated lungs were apparent by 21 days of MCT treatment. The magnitude of the changes in all parameters increased with duration of treatment. After 28 days of treatment biliary indocyanine green excretion was decreased and plasma glutamic pyruvic transaminase acitivty was slightly elevated. Treatment (28 days) also resulted in elevated blood urea N, decreased accumulation of p-aminohippuric acid by kidney slices and increased accumulation of tetraethylammonium by kidney slices. Lung, liver and kidney were each affected by this MCT treatment regimen and functional effects on lung preceded effects on other tissues.