Cell junctions in fish seminiferous epithelium
Cell junctions in fish seminiferous epithelium
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DOI：
10.1007/s10695-008-9253-y
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发表时间：
2009-03-01
影响因子：
2.9
通讯作者：
Franca, L. R.
中科院分区：
文献类型：
--
作者：
Batlouni, S. R.;Nobrega, R. H.;Franca, L. R.
与哺乳动物相似，鱼类生精上皮中支持细胞（SC）和生殖细胞（GC）之间的细胞相互作用具有重要的结构和功能作用。在这篇综述中，我们简要总结了这些相互作用，特别是那些对细胞连接。尽管缺乏详细的经验数据，它似乎是两个基本类型的粘合剂连接（肌动蛋白和中间体相关）之间存在SC。然而，肌动蛋白相关的多功能连接被称为“外质专业化”似乎只存在于一些软骨鱼。相反，SC在其他鱼类中加入肌动蛋白相关的路口，类似于典型的小带或附着点在其他上皮细胞。在SC和GC之间以及GC和GC之间也发现了粘附连接，并且由于它们的特定特征，这些连接被称为“桥粒样连接”。在细胞间通讯方面，已经证明在鱼类SC之间存在连接蛋白和间隙连接，并且它们可能参与协调囊内GC的同步发育。间隙连接也可能在囊肿内的SC和GC之间形成互连网络。关于SC屏障，鱼类SC之间的紧密连接显然只在含有单倍体GC的包囊中形成功能性屏障，并且与哺乳动物不同，鱼类中的减数分裂GC不被血管系统屏蔽。总之，虽然还没有得到很好的研究，在鱼的生精上皮细胞间的相互作用似乎是至关重要的GC的发展，和他们的干扰，例如通过改变环境条件，可能会影响GC的生存和生育能力。
Similar to mammals, in fish the cellular interactions between Sertoli cells (SC) and germ cells (GC) in the seminiferous epithelium have important structural and functional roles. In this review, we give a brief summary of these interactions, in particular those on the cell junctions. Despite the scarcity of detailed empirical data, it appears that both basic types of adhesive junctions (actin- and intermediate filaments-related) are present between SC. However, the actin-related multifunctional junction known as the "ectoplasmic specialization" is seemingly present only in some cartilaginous fish. Conversely, SC in other fish species are joined by actin-related junctions similar to typical zonulae or puncta adherens found in other epithelia. Adhesive junctions are also found between SC and GC and between GC and GC, and due to their particular characteristics these junctions are known as "desmosome-like junctions". In terms of intercellular communication, connexins and gap junctions have been shown to occur between SC in fish, and they may be involved in the coordination of the synchronous development of GC within the cysts. It is also possible that gap junctions may form an interconnected network between SC and GC within a cyst. Concerning the SC barrier, tight junctions between fish SC apparently form a functional barrier only in cysts containing haploid GC, and different from mammals, meiotic GC in fish are not shielded from the vascular system. In summary, although still not well investigated, cell-cell interactions in the seminiferous epithelium of fish seem to be crucial for GC development, and their disturbance, for example by changing environmental conditions, will probably affect GC survival and fertility.