A comparison of inflammation-based prognostic scores in patients with cancer. A Glasgow Inflammation Outcome Study
A comparison of inflammation-based prognostic scores in patients with cancer. A Glasgow Inflammation Outcome Study
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DOI：
10.1016/j.ejca.2011.03.028
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发表时间：
2011-11-01
影响因子：
8.4
通讯作者：
McMillan, Donald C.
中科院分区：
文献类型：
--
作者：
Proctor, Michael J.;Morrison, David S.;McMillan, Donald C.
系统性炎症反应的组成部分，结合形成基于炎症的预后评分（改良格拉斯哥预后评分（mGPS），中性粒细胞淋巴细胞比率（NLR），血小板淋巴细胞比率（PLR），预后指数（PI），预后营养指数（PNI））与癌症特异性生存相关。本研究的目的是比较这些评分的预后价值。方法：在2000年至2007年间采集c反应蛋白、白蛋白、白细胞、中性粒细胞、淋巴细胞和血小板计数以及癌症诊断（苏格兰癌症登记处）的患者（n = 27,031）进行鉴定。在这一组中，有8759名患者在癌症诊断后的两年内被抽样调查。结果：随访中死亡5163例，其中癌症死亡4417例（86%）。从抽血到诊断的中位时间为1.7个月。升高的mGPS、NLR、PLR、PI和PNI可预测癌症特异性生存率降低，与年龄、性别、剥夺和肿瘤部位无关
Introduction: Components of the systemic inflammatory response, combined to form inflammation-based prognostic scores (modified Glasgow Prognostic Score (mGPS), Neutrophil Lymphocyte Ratio (NLR), Platelet Lymphocyte Ratio (PLR), Prognostic Index (PI), Prognostic Nutritional Index (PNI)) have been associated with cancer specific survival. The aim of the present study was to compare the prognostic value of these scores.Methods: Patients (n = 27,031) who had an incidental blood sample taken between 2000 and 2007 for C-reactive protein, albumin, white cell, neutrophil, lymphocyte and platelet counts, as well as a diagnosis of cancer (Scottish Cancer Registry) were identified. Of this group 8759 patients who had been sampled within two years following their cancer diagnosis were studied.Results: On follow up, there were 5163 deaths of which 4417 (86%) were cancer deaths. The median time from blood sampling to diagnosis was 1.7 months. An elevated mGPS, NLR, PLR, PI and PNI were predictive of a reduced cancer specific survival independent of age, sex and deprivation and tumour site (all p