Post-weaning multisystemic wasting syndrome (PMWS) in pigs in France:: clinical observations from follow-up studies on affected farms
Post-weaning multisystemic wasting syndrome (PMWS) in pigs in France:: clinical observations from follow-up studies on affected farms
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DOI：
10.1016/s0301-6226(99)00138-4
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发表时间：
2000-05-01
期刊：
影响因子：
--
通讯作者：
Jestin, A
中科院分区：
文献类型：
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作者：
Madec, F;Eveno, E;Jestin, A
在法国农场描述了一种影响断奶仔猪的疾病，称为断奶后多系统衰竭综合征（PMWS）。对一组12头严重受影响的仔猪至终末手术的猪队列设计了随访研究。其中3只没有感染猪繁殖与呼吸综合征病毒。本研究纳入了3078头猪。从断奶到屠宰的死亡率为11%，第11-13周是最关键的。第一个临床症状是消瘦，然后是苍白，经常伴有呼吸或消化系统疾病的发热。消瘦可能很快发生，当在个体中明确确定时，预后是严重的，特别是当病猪与其圈养动物一起饲养时。使用抗生素没有真实的疗效。病变累及多个脏器，包括肺、脾、肾和淋巴结，伴有重度淋巴耗竭。这种疾病没有显示出集体影响。从初步流行病学调查，一个强大的窝疾病易感性的影响被怀疑。PRRS病毒被排除为主要病原体。另一方面，发现猪圆环病毒（PCV 2）与病变相关。环境被怀疑是PMWS在畜群中作用的重要决定因素。
A disease affecting weaned pigs and known as Postweaning Multisystemic Wasting Syndrome (PMWS) is described on French farms. Follow-up studies were designed on cohorts of pigs on a group of 12 severely affected farrow-to-finish operations. Three of them were free of Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) infection. Three thousand and seventy eight pigs were included in the study. Mortality, from weaning to slaughter, was 11% and weeks 11-13 were the most critical. The first clinical sign reported was unthriftiness, then pallor and often fever with associated respiratory or digestive disorders. Wasting could follow rapidly and when clearly established in an individual the prognosis was grave especially when the sick pigs were kept with their penmates. Antibiotics were administered without real efficacy. The lesions affected several viscera including lungs, spleen, kidneys and lymph nodes with a severe lymphoid depletion. The disease did not show a collective impact. From preliminary epidemiological investigations, a strong litter effect on disease susceptibility was suspected. PRRS virus was excluded as a major agent. On the other hand, a porcine circovirus (PCV2) was found associated to the lesions. The environment was suspected as an important determining factor for the effect of PMWS in the herds.