Leukemia inhibitory factor (LIF).
Leukemia inhibitory factor (LIF).
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DOI：
10.1016/j.cytogfr.2015.07.001
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发表时间：
2015-10
影响因子：
13
通讯作者：
Babon JJ
中科院分区：
文献类型：
--
作者：
Nicola NA;Babon JJ
白血病抑制因子 (LIF) 是细胞因子 IL-6 家族中最具多效性的成员。它利用由 LIF 受体 β 和 gp130 组成的受体，该受体复合物也被睫状神经营养生长因子 (CNTF)、制瘤素 M、心肌营养素 1 (CT1) 和心肌营养素样细胞因子 (CLC) 使用。尽管有常见的信号转导机制（JAK/STAT、MAPK 和 PI3K），但 LIF 在不同的细胞类型中可能具有相反的作用，包括刺激或抑制每种细胞增殖、分化和存活。虽然 LIF 可以作用于多种细胞类型，但 LIF 敲除小鼠发现，其中许多作用在正常发育过程中并不明显，它们可能是组织损伤或损伤过程中诱导 LIF 表达的结果。尽管如此，LIF 似乎在母体对囊胚植入的接受性、胎盘形成和神经系统发育方面确实具有非冗余作用。 LIF 还实际用于维持胚胎干细胞和诱导多能干细胞的自我更新和全能性。
Leukemia inhibitory factor (LIF) is the most pleiotropic member of the interleukin-6 family of cytokines. It utilises a receptor that consists of the LIF receptor β and gp130 and this receptor complex is also used by ciliary neurotrophic growth factor (CNTF), oncostatin M, cardiotrophin1 (CT1) and cardiotrophin-like cytokine (CLC). Despite common signal transduction mechanisms (JAK/STAT, MAPK and PI3K) LIF can have paradoxically opposite effects in different cell types including stimulating or inhibiting each of cell proliferation, differentiation and survival. While LIF can act on a wide range of cell types, LIF knockout mice have revealed that many of these actions are not apparent during ordinary development and that they may be the result of induced LIF expression during tissue damage or injury. Nevertheless LIF does appear to have non-redundant actions in maternal receptivity to blastocyst implantation, placental formation and in the development of the nervous system. LIF has also found practical use in the maintenance of self-renewal and totipotency of embryonic stem cells and induced pluripotent stem cells.