Relationship Between Anemia, Malaria Coinfection, and Kaposi Sarcoma-Associated Herpesvirus Seropositivity in a Population-Based Study in Rural Uganda
Relationship Between Anemia, Malaria Coinfection, and Kaposi Sarcoma-Associated Herpesvirus Seropositivity in a Population-Based Study in Rural Uganda
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DOI：
10.1093/infdis/jiy274
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发表时间：
2018-10-01
影响因子：
6.4
通讯作者：
Newton, Robert
中科院分区：
文献类型：
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作者：
Nalwoga, Angela;Cose, Stephen;Newton, Robert
我们研究了贫血和疟疾作为Kaposi肉瘤相关疱疹病毒(KSHV)血清阳性和抗体水平的危险因素，在乌干达农村长期流行KSHV。对4134名1~17岁1：1的儿童和3149名18~103岁的成年人(其中41%为男性)进行了样本分析。在儿童中，疟疾感染与较高的KSHV流行率有关(在感染疟疾和未感染疟疾的人群中，患病率分别为61%和41%)；成人中没有评估疟疾。此外，在儿童和成人中，较低的血红蛋白水平与KSHV血清阳性患病率的增加有关。
We examined anemia and malaria as risk factors for Kaposi sarcoma-associated herpesvirus (KSHV) seropositivity and antibody levels in a long-standing rural Ugandan cohort, in which KSHV is prevalent. Samples from 4134 children, aged 1-17 years, with a sex ratio of 1:1, and 3149 adults aged 18-103 years, 41% of whom were males, were analyzed. Among children, malaria infection was associated with higher KSHV prevalence (61% vs 41% prevalence among malaria infected and uninfected, respectively); malaria was not assessed in adults. Additionally, lower hemoglobin level was associated with an increased prevalence of KSHV seropositivity, both in children and in adults.