Body Mass Index and Decline in Cognitive Function in Older Black and White Persons
Body Mass Index and Decline in Cognitive Function in Older Black and White Persons
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DOI：
10.1093/gerona/glx152
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发表时间：
2018-02-01
影响因子：
5.1
通讯作者：
Barnes, Lisa L.
中科院分区：
文献类型：
--
作者：
Arvanitakis, Zoe;Capuano, Ana W.;Barnes, Lisa L.
背景资料：虽然黑人的体重指数（BMI）高于白色人，但对黑人比例较大的队列中的BMI和认知变化知之甚少。我们在老年黑人和白人中研究了BMI与整体认知和五个认知领域下降的关系，并确定了这种关系是否因种族而异。（33%黑人; 75%妇女;平均年龄= 77.9 [范围53-100]和教育= 14.7年，简易精神状态检查= 28.0），入组两个纵向之一，少数民族老龄化研究（Minority Aging Research Study; Rush Memory and Aging Project）。全球认知和五个领域的总分是基于每年进行的19项神经心理学测试。混合效应模型，控制年龄，性别，教育，和种族，被用来检查基线BMI的关系，以改变cognition.Results：基线BMI = 28.4单位（30.3在黑人[95%置信区间（CI）：27.2-27.7]; 27.4在白人[95%CI：29.8-30.7]）。在平均每年随访6年（SD = 4）期间，较低的基线BMI与整体认知（p = .002）、语义记忆（p < .001）和情景记忆（p = .004）的快速下降有关，但与工作记忆、感知速度或视觉空间能力无关（所有p > .08）。BMI与认知变化的关系不受种族的影响（所有p > 0.09）。结论：在黑人和白人中，晚年较低的BMI与认知下降的速度更快有关，特别是语义记忆和情景记忆。BMI对认知的影响在两个种族群体中似乎是相似的。
Background: While body mass index (BMI) is higher in black compared to white persons, little is known about BMI and change in cognition in cohorts with a large proportion of blacks. We examine relations of BMI with decline in global cognition and five cognitive domains, in older blacks and whites, and determine whether relations differ by race.Methods: Participants were 2,134 persons without baseline dementia (33% black; 75% women; mean age = 77.9 [range 53-100] and education = 14.7 years, Mini-Mental State Examination = 28.0), enrolled in one of two longitudinal, community-based cohort studies of aging (Minority Aging Research Study; Rush Memory and Aging Project). Summary scores of global cognition and five domains were based on 19 neuropsychological tests administered annually. Mixed-effects models, controlling for age, sex, education, and race, were used to examine the relation of baseline BMI to change in cognition.Results: Baseline BMI = 28.4 units (30.3 in blacks [95% confidence interval (CI): 27.2-27.7]; 27.4 in whites [95% CI: 29.8-30.7]). During a mean annual follow-up of 6 years (SD = 4), lower baseline BMI was related to faster decline in global cognition (p = .002), and semantic memory (p < .001) and episodic memory (p = .004), but not working memory, perceptual speed, or visuospatial ability (all p > .08). The relationship of BMI with change in cognition was not modified by race (all p > .09).Conclusions: Late-life lower BMI relates to faster rates of decline in cognition, specifically semantic memory and episodic memory, in both blacks and whites. The effect of BMI on cognition appears to be similar in both racial groups.