MATERNAL AND GESTATIONAL FACTORS IN CRYPTORCHIDISM
MATERNAL AND GESTATIONAL FACTORS IN CRYPTORCHIDISM
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DOI：
10.1093/ije/20.4.964
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发表时间：
1991-12-01
影响因子：
7.7
通讯作者：
GALLAGHER, RP
中科院分区：
文献类型：
--
作者：
MCBRIDE, ML;VANDENSTEEN, N;GALLAGHER, RP
以前对隐睾症的流行病学研究导致了一种假设，即隐睾症的风险与怀孕期间过量的雌激素暴露有关。为了验证这一假设，进行了一项病例对照研究，比较了从不列颠哥伦比亚省随机选择的病例后六个月内出生的受影响男孩的母亲(244人)和正常男性出生的母亲(488人)。收集了母亲的生育史、家族史和过去的病史，以及围绕着所有怀孕以分娩结束的事件的信息。分析结果使用了以人口为基础的男婴样本和病例的男性同胞作为对照组。无论是外源性雌激素暴露，还是任何被假设为内源性雌激素暴露的间接指标的妊娠相关变量，包括出血、恶心和/或呕吐，在这两种比较中都没有发现与睾丸未下降的风险显著相关。更多指征出生较晚的母亲报告月经不规律的时间超过一半，被认为具有保护作用的吸烟在病例母亲中比对照母亲更普遍。病例母亲和对照母亲之间没有其他变量有显著差异。这项研究的结果不支持这样的假设，即怀孕期间外源性或内源性雌激素暴露增加了男性儿童睾丸未下降的风险。
Previous epidemiological studies of cryptorchidism have led to the hypothesis that the risk of undescended testis is associated with excess oestrogen exposure during pregnancy. A case-control study was undertaken to test this hypothesis, comparing mothers of affected boys (244) and normal male births (488) born within six months of a case selected randomly from the British Columbia population. Information was collected on the mother's reproductive history, family history, and past medical history, and events surrounding all pregnancies ending in a birth. The results were analysed using both the population-based sample of male births and the male sibs of cases as control groups. Neither exogenous oestrogen exposure, nor any of the pregnancy-related variables hypothesized to be indirect indicators of endogenous oestrogen exposure, including bleeding and nausea and/or vomiting, were found to be significantly associated with risk of undescended testes in either comparison. More mothers with later index births reported menstrual irregularity greater than half the time, and smoking, thought to have a protective effect, was more prevalent among case mothers than control mothers. No other variables were significantly different between case and control mothers. The results of this study do not support the hypothesis that elevated exogenous or endogenous oestrogen exposure during pregnancy increases the risk of undescended testis in male children.