Association between antidepressant use and second breast cancer event after ductal carcinoma in situ diagnosis: a nested case-control study.
Association between antidepressant use and second breast cancer event after ductal carcinoma in situ diagnosis: a nested case-control study.
复制标题
抗抑郁药物的使用与导管原位癌诊断后第二次乳腺癌事件之间的关联：一项巢式病例对照研究。
DOI：
10.1007/s10552-021-01551-w
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Li,ChristopherI
中科院分区：
文献类型：
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作者：
Mansi,ElizabethT;Malone,KathleenE;Tang,Mei-Tzu;Loroña,NicoleC;Li,ChristopherI
抗抑郁药使用与乳腺癌风险之间的潜在关系存在争议。没有以前的研究已经评估了抗抑郁药的使用后，诊断导管原位癌（DCIS）和随后的乳腺癌的风险之间的关系，仅限于妇女的历史DCIS.MethodsWe进行了一项以人群为基础的，嵌套的病例对照研究，在西部华盛顿州。病例包括337名被诊断为DCIS和随后的乳腺癌的妇女，并将其与592名被诊断为DCIS但没有随后的乳腺癌的个体匹配对照（年龄，DCIS诊断年，主要治疗，组织学，分级和无病生存时间）进行比较。DCIS诊断后使用抗抑郁药的信息来自全面的病历审查。抗抑郁药的使用被定义为大于或等于3个月的duration. ResultsAntihepatitis使用后，初始DCIS与随后的乳腺癌事件的风险增加1.4倍（调整OR 1.41，95%CI 1.02，1.95）。类似的风险进行评估时，个别抗抑郁类，但是，没有足够的权力在特定类别的抗抑郁药。结论DCIS诊断后使用抗抑郁药与随后的乳腺癌的风险增加的妇女。需要进一步的研究来证实观察到的相关性。
PurposeControversy exists regarding the potential relationship between antidepressant use and risk of breast cancer. No previous studies have evaluated the relationship between antidepressant use after diagnosis of ductal carcinoma in situ (DCIS) and risk of a subsequent breast cancer restricted to women with a history of DCIS.MethodsWe conducted a population-based, nested case–control study in western Washington State. Cases included 337 women diagnosed with DCIS and a subsequent breast cancer and they were compared to 592 individually matched controls (on age, year of DCIS diagnosis, primary treatment, histology, grade, and disease-free survival time) who were diagnosed with DCIS but not a subsequent breast cancer. Information on antidepressant use after DCIS diagnosis was obtained from comprehensive medical records reviews. Antidepressant use was defined as greater or equal to 3 months of duration.ResultsAntidepressant use after initial DCIS was associated with a 1.4-fold increased risk of a subsequent breast cancer event (adjusted OR 1.41, 95% CI 1.02, 1.95). Similar risks were observed when assessing individual antidepressant classes, however, there was no sufficient power across specific classes of antidepressants.ConclusionsAntidepressant use after DCIS diagnosis was associated with an increased risk of subsequent breast cancer in women. Further studies are needed to confirm the associations observed.