Biological and clinical relevance of stem cells in pancreatic adenocarcinoma.
Biological and clinical relevance of stem cells in pancreatic adenocarcinoma.
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DOI：
10.1111/j.1440-1746.2011.07015.x
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发表时间：
2012-03
影响因子：
4.1
通讯作者：
Matsui W
中科院分区：
文献类型：
--
作者：
Rasheed ZA;Matsui W
肿瘤干细胞（CSC）已在越来越多的人类恶性肿瘤中被发现。CSC在功能上由其在异位环境中自我更新和重演肿瘤的能力来定义，并且越来越多的研究表明它们显示出其他功能特征，例如侵袭和耐药性。这些独特的功能特性暗示了CSC在临床结果中的作用，例如初始肿瘤形成、治疗后复发、转移和耐药性，表明它们是指导临床结果的主要因素。胰腺癌是一种高度侵袭性的疾病，具有早期转移和耐药性的倾向。已使用细胞表面抗原CD 44、CD 24和CD 133以及醛脱氢酶（ALDH）的高表达来鉴定致瘤性胰腺癌细胞。体外和体内研究表明，表达ALDH和CD133的胰腺CSC具有更大的转移倾向，并且表达ALDH的CSC已被证明对常规化疗具有抗性。在来自胰腺癌切除患者的临床样本中，表达ALDH的CSC的存在与较差的总生存率相关。CSC靶向治疗的发展可能对改变患有这种疾病的患者的临床结果很重要，我们已经开始鉴定阻断CSC功能的新型化合物。这篇综述将讨论CSC在胰腺癌中的生物学和临床意义，并将讨论针对它们的新的治疗策略。
Cancer stem cells (CSC) have been identified in a growing number of human malignancies. CSC are functionally defined by their ability to self-renew and recapitulate tumors in the ectopic setting, and a growing number of studies have shown that they display other functional characteristics, such as invasion and drug resistance. These unique functional properties implicate a role for CSC in clinical consequences, such as initial tumor formation, relapse following treatment, metastasis, and resistance, suggesting they are a major factor in directing clinical outcomes. Pancreatic adenocarcinoma is a highly-aggressive disease with a propensity for early metastasis and drug resistance. Tumorigenic pancreatic cancer cells have been identified using the cell surface antigens CD44, CD24, and CD133, as well as the high expression of aldehyde dehydrogenase (ALDH). In vitro and in vivo studies have shown that ALDH- and CD133-expressing pancreatic CSC have a greater propensity for metastasis, and ALDH-expressing CSC have been shown to be resistant to conventional chemotherapy. In clinical samples from patients with resected pancreatic adenocarcinoma, the presence of ALDH-expressing CSC was associated with worse overall survival. The development of CSC-targeting therapies might be important in changing the clinical outcomes of patients with this disease, and others and we have begun to identify novel compounds that block CSC function. This review will discuss the biological and clinical relevance of CSC in pancreatic cancer, and will discuss novel therapeutic strategies to target them.
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影响因子：
11.2
作者：
Huang EH;Hynes MJ;Zhang T;Ginestier C;Dontu G;Appelman H;Fields JZ;Wicha MS;Boman BM
通讯作者：
Boman BM
影响因子：
64.5
作者：
Duester G
通讯作者：
Duester G
影响因子：
5.7
作者：
Feldmann G;Fendrich V;McGovern K;Bedja D;Bisht S;Alvarez H;Koorstra JB;Habbe N;Karikari C;Mullendore M;Gabrielson KL;Sharma R;Matsui W;Maitra A
通讯作者：
Maitra A
DOI：
10.1073/pnas.0912589107
发表时间：
2010-01-05
影响因子：
11.1
作者：
Rovira, Meritxell;Scott, Sherri-Gae;Leach, Steven D.
通讯作者：
Leach, Steven D.
影响因子：
29.4
作者：
Li, Chenwei;Wu, Jing-Jiang;Simeone, Diane M.
通讯作者：
Simeone, Diane M.