For better or worse: genomic consequences of intracellular mutualism and parasitism.
For better or worse: genomic consequences of intracellular mutualism and parasitism.
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无论好坏：细胞内互利共生和寄生的基因组后果。
DOI：
10.1016/j.gde.2005.09.013
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发表时间：
2005
影响因子：
4
通讯作者：
Wernegreen,JenniferJ
中科院分区：
文献类型：
--
作者：
Wernegreen,JenniferJ
在真核宿主细胞内复制的细菌包括多种致病性和互惠物种。早期的基因组数据表明，这些细胞内的联营公司，他们经历了持续的基因丢失，很少，如果有任何基因收购，和最小的重组在小，孤立的群体。这种还原进化的观点本身也在不断发展，因为新的基因组序列阐明了各种细胞内关联的机制和结果。最近的基因组测序证实了基因丢失的轨迹和特殊的基因组稳定性在长期，营养互惠和某些病原体。然而，立克次体目和衣原体目的新基因组数据表明，与以前对古老细胞内谱系的怀疑相比，它们有更多的重复DNA，更丰富的移动的DNA元件，以及更不稳定的基因组动态。在寄生虫猫立克次体和阿米巴共生体副衣原体中令人惊讶的接合机制的发现表明，DNA转移可能在一些细胞内类群中发挥关键作用。
Bacteria that replicate within eukaryotic host cells include a variety of pathogenic and mutualistic species. Early genome data for these intracellular associates suggested they experience continual gene loss, little if any gene acquisition, and minimal recombination in small, isolated populations. This view of reductive evolution is itself evolving as new genome sequences clarify mechanisms and outcomes of diverse intracellular associations. Recently sequenced genomes have confirmed a trajectory of gene loss and exceptional genome stability in long-term, nutritional mutualists and certain pathogens. However, new genome data for the Rickettsiales and Chlamydiales indicate more repeated DNA, a greater abundance of mobile DNA elements, and more labile genome dynamics than previously suspected for ancient intracellular lineages. Surprising discoveries of conjugation machinery in the parasite Rickettsia felis and the amoebae symbiont Parachlamydia sp. suggest that DNA transfer might play key roles in some intracellular taxa.