Glycated Hemoglobin and the Risk of Kidney Disease and Retinopathy in Adults With and Without Diabetes
Glycated Hemoglobin and the Risk of Kidney Disease and Retinopathy in Adults With and Without Diabetes
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DOI：
10.2337/db10-1198
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发表时间：
2011-01-01
期刊：
影响因子：
7.7
通讯作者：
Coresh, Josef
中科院分区：
文献类型：
--
作者：
Selvin, Elizabeth;Ning, Yang;Coresh, Josef
目的-糖化血红蛋白最近被推荐用作糖尿病的诊断测试。我们检查了 2010 年美国糖尿病协会糖化血红蛋白诊断切点与微血管结果（慢性肾病、终末期肾病 [ESRD] 和视网膜病变）之间的关联，并正式测试了糖化血红蛋白与这些结果之间关系中是否存在风险阈值。 研究设计和方法 - 对来自美国的 11,357 名参与者（773 名有诊断糖尿病史）进行前瞻性队列和横断面分析。社区动脉粥样硬化风险 (ARIC) 研究。结果 - 在对基线时未诊断出糖尿病的个体进行平均 14 年的随访期间，糖化血红蛋白的临床类别与慢性肾脏病的风险相关，糖化血红蛋白的调整后风险比 (HR) 分别为 1.12 (0.94-1.34) 和 1.39 (1.04-1.85)与 相比，分别为 5.7-6.4% 和 >= 6.5%
OBJECTIVE-Glycated hemoglobin was recently recommended for use as a diagnostic test for diabetes. We examined the association between 2010 American Diabetes Association diagnostic cut points for glycated hemoglobin and microvascular outcomes (chronic kidney disease, end-stage renal disease [ESRD], and retinopathy) and formally tested for the presence of risk thresholds in the relationships of glycated hemoglobin with these outcomes.RESEARCH DESIGN AND METHODS-Prospective cohort and cross-sectional analyses of 11,357 participants (773 with a history of diagnosed diabetes) from the Atherosclerosis Risk in Communities (ARIC) Study.RESULTS-During a median of 14 years of follow-up of individuals without diagnosed diabetes at baseline, clinical categories of glycated hemoglobin were associated with risk of chronic kidney disease, with adjusted hazard ratios (HRs) of 1.12 (0.94-1.34) and 1.39 (1.04-1.85) for glycated hemoglobin 5.7-6.4% and >= 6.5%, respectively, as compared with