Hippocampus, Delay Discounting, and Vicarious Trial-and-Error
Hippocampus, Delay Discounting, and Vicarious Trial-and-Error
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DOI：
10.1002/hipo.22400
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发表时间：
2015-05-01
期刊：
影响因子：
3.5
通讯作者：
Dudchenko, Paul A.
中科院分区：
文献类型：
--
作者：
Bett, David;Murdoch, Lauren H.;Dudchenko, Paul A.
在决策中，即时奖励通常比延迟奖励更受欢迎，即使后者更大。我们测试了海马体是否是这种形式的时间折扣所必需的，以及在决策点的替代试错。对大鼠进行最近开发的可调节延迟折扣任务（Papale等人（2012）Cogn Affect Behav Neurosci 12：513-526）的训练，其特征在于在小的几乎立即的奖励和较大的延迟奖励之间进行选择。然后大鼠接受海马或假损伤。海马损伤的动物调整延迟较大的奖励的水平类似于假损伤的动物，这表明类似的估值能力。然而，海马损伤组花了显着更长的时间调查的小和大的奖励在第一部分的会议，并不太敏感的奖励金额的变化，在大的奖励迷宫arm. Both假和海马损伤大鼠表现出更大的量的替代试错试验中，延迟进行了调整。在延迟折扣任务的非调整版本中，与假损伤动物相比，海马损伤动物对延迟10 s的更大奖励的偏好表现出更大的变异性。为了验证损伤的行为，随后对大鼠进行水迷宫任务训练，与假损伤动物相比，海马损伤的大鼠明显受损。对延迟折扣任务的研究结果表明，海马的损伤可能会损害奖励幅度的检测。(c)2014 Wiley Periodicals，Inc.
In decision-making, an immediate reward is usually preferred to a delayed reward, even if the latter is larger. We tested whether the hippocampus is necessary for this form of temporal discounting, and for vicarious trial-and-error at the decision point. Rats were trained on a recently developed, adjustable delay-discounting task (Papale et al. (2012) Cogn Affect Behav Neurosci 12:513-526), which featured a choice between a small, nearly immediate reward, and a larger, delayed reward. Rats then received either hippocampus or sham lesions. Animals with hippocampus lesions adjusted the delay for the larger reward to a level similar to that of sham-lesioned animals, suggesting a similar valuation capacity. However, the hippocampus lesion group spent significantly longer investigating the small and large rewards in the first part of the sessions, and were less sensitive to changes in the amount of reward in the large reward maze arm. Both sham- and hippocampus-lesioned rats showed a greater amount of vicarious trial-and-error on trials in which the delay was adjusted. In a nonadjusting version of the delay discounting task, animals with hippocampus lesions showed more variability in their preference for a larger reward that was delayed by 10 s compared with sham-lesioned animals. To verify the lesion behaviorally, rat were subsequently trained on a water maze task, and rats with hippocampus lesions were significantly impaired compared with sham-lesioned animals. The findings on the delay discounting tasks suggest that damage to the hippocampus may impair the detection of reward magnitude. (c) 2014 Wiley Periodicals, Inc.