Alteration in the function of cerebral neurotransmitter receptors during the establishment of alcohol dependence: neurochemical aspects.
Alteration in the function of cerebral neurotransmitter receptors during the establishment of alcohol dependence: neurochemical aspects.
复制标题
酒精依赖建立过程中脑神经递质受体功能的改变：神经化学方面。
DOI：
10.1093/oxfordjournals.alcalc.a044997
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发表时间：
1990
影响因子：
2.8
通讯作者：
S. Ohkuma
中科院分区：
文献类型：
--
作者：
K. Kuriyama;S. Ohkuma
慢性酒精治疗会对神经递质的代谢及其受体的功能产生多种影响。最近关于酒依赖和/或功能性酒精耐受的研究清楚地表明，神经递质门控和受体偶联离子通道，以及与细胞内介质系统耦合的神经递质受体，如磷脂酰肌醇和环核苷酸生成系统，在酒依赖过程中总是受到抑制。因此，未来对酒精的中枢作用和酒精依赖的研究应针对神经递质受体等突触膜结合成分的分子变化，以及神经递质释放和相关的膜结合酶。
Chronic alcohol treatment induces a variety of effects on the metabolism of neurotransmitters and the function of their receptors. Recent studies on alcohol dependence and/or functional tolerance to alcohol have clearly demonstrated that neurotransmitter-gated and receptor-coupled ion channels, as well as neurotransmitter receptor coupled with intracellular mediator systems, such as phosphatidylinositides and cyclic nucleotide-generating systems, are invariably suppressed during alcohol dependence. Future studies on the central actions of alcohol and on alcohol dependence should therefore be directed at the molecular changes in synaptic membrane-bound components such as neurotransmitter receptors, as well as on neurotransmitter release and relevant membrane-bound enzymes.